ArticleVirulence2018
Boosted TCA cycle enhances survival of zebrafish to Vibrio alginolyticus infection.
Article in Virulence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 66 citations in OpenAlex.
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- Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17/Treg balance and enhancing Lactobacillus colonization in piglets.Journal of animal science and biotechnology · 2024Article
- Inosine reverses multidrug resistance in Gram-negative bacteria carrying mobilized RND-type efflux pump gene clustermSystems · 2024Article
- Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites.Frontiers in immunology · 2024Article
- The probiotic effects of host-associatedAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Oleic acid as potential immunostimulant in metabolism pathways of hybrid grouper fingerlings (Epinephelus fuscoguttatus × Epinephelus lanceolatus) infected with Vibrio vulnificus.Scientific reports · 2023Article
- Targeting NAD+ regeneration enhances antibiotic susceptibility of Streptococcus pneumoniae during invasive disease.PLoS biology · 2023Article
- Comprehensive insights into the metabolism characteristics of small RNA Qrr4 in Vibrio alginolyticus.Applied microbiology and biotechnology · 2023Article
- Fructose potentiates the protective efficiency of liveFrontiers in immunology · 2023Article
- Taurine metabolism is modulated in Vibrio-infected Penaeus vannamei to shape shrimp antibacterial response and survival.Microbiome · 2022Article
- Exogenous metabolite feeding on altering antibiotic susceptibility in Gram-negative bacteria through metabolic modulation: a review.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Metabolomic Effects of the Dietary Inclusion ofMetabolites · 2022Article
- A Comparative Analysis of Metabolic Profiles of Embryonic Skeletal Muscle from Lantang and Landrace Pigs.Animals : an open access journal from MDPI · 2022Article
- Temperature induces metabolic reprogramming in fish during bacterial infection.Frontiers in immunology · 2022Article
- Functional proteomics identify mannitol metabolism in serum resistance and therapeutic implications inFrontiers in immunology · 2022Article
- Serine Metabolism Tunes Immune Responses To PromotemSystems · 2021Article
- Succinate Promotes Phagocytosis of Monocytes/Macrophages in Teleost Fish.Frontiers in molecular biosciences · 2021Article
- Activation of the TCA Cycle to Provide Immune Protection in Zebrafish Immunized by High Magnesium-PreparedFrontiers in immunology · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio alginolyticus is a waterborne pathogen that infects a wide variety of hosts including fish and human, and the outbreak of this pathogen can cause a huge economic loss in aquaculture. Thus, enhancing host's capability to survive from V. alginolyticus infection is key to fighting infection and this remains still unexplored. In the present study, we established a V. alginolyticus-zebrafish interaction model by which we explored how zebrafish survived from V. alginolyticus infection. We used GC-MS based metabolomic approaches to characterize differential metabolomes between survival and dying zebrafish upon infection. Pattern recognition analysis identified the TCA cycle as the most impacted pathway. The metabolites in the TCA cycle were decreased in the dying host, whereas the metabolites were increased in the survival host. Furthermore, the enzymatic activities of the TCA cycle including pyruvate dehydrogenase (PDH), α-ketoglutaric dehydrogenase (KGDH) and succinate dehydrogenase (SDH) also supported this conclusion. Among the increased metabolites in the TCA cycle, malic acid was the most crucial biomarker for fish survival. Indeed, exogenous malate promoted zebrafish survival in a dose-dependent manner. The corresponding activities of KGDH and SDH were also increased. These results indicate that the TCA cycle is a key pathway responsible for the survival or death in response to infection caused by V. alginolyticus, and highlight the way on development of metabolic modulation to control the infection.
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