Evidence map›Paper›PMID 29338384›Full record

ArticleCell transplantation2017

Human Umbilical Cord Mesenchymal Stem Cells Preserve Adult Newborn Neurons and Reduce Neurological Injury after Cerebral Ischemia by Reducing the Number of Hypertrophic Microglia/Macrophages.

Willie Lin, Yogi Chang-Yo Hsuan, Mao-Tsun Lin, Ting-Wei Kuo, Cheng-Hsien Lin, Yu-Chin Su, Ko-Chi Niu, Ching-Ping Chang, Hung-Jung Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Willie Lin1 Meridigen Biotech Co., Ltd., Neihu, Taipei City, Taiwan.
Yogi Chang-Yo Hsuan1 Meridigen Biotech Co., Ltd., Neihu, Taipei City, Taiwan.
Mao-Tsun Lin2 Department of Medical Research, Chi Mei Medical Center, Tainan City, Taiwan.
Ting-Wei Kuo3 Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan City, Taiwan.
Cheng-Hsien Lin1 Meridigen Biotech Co., Ltd., Neihu, Taipei City, Taiwan.
Yu-Chin Su1 Meridigen Biotech Co., Ltd., Neihu, Taipei City, Taiwan.
Ko-Chi Niu4 Department of Hyperbaric Oxygen, Chi Mei Medical Center, Tainan City, Taiwan.
Ching-Ping Chang2 Department of Medical Research, Chi Mei Medical Center, Tainan City, Taiwan.ORCID 0000-0003-0890-9414
Hung-Jung Lin3 Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan City, Taiwan.
Chi Mei Medical Center · TWSouthern Taiwan University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are the first source of a neuroinflammatory cascade, which seems to be involved in every phase of stroke-related neuronal damage. Two weeks after transient middle cerebral artery occlusion (MCAO), vehicle-treated rats displayed higher numbers of total ionized calcium-binding adaptor molecule 1 (Iba-1)-positive cells, greater cell body areas of Iba-1-positive cells, and higher numbers of hypertrophic Iba-1-positive cells (with a cell body area over 80 μm

Indexed as

Analysis of VarianceAnimalsBrain IschemiaCell- and Tissue-Based TherapyCell ProliferationDisease Models, AnimalDoublecortin ProteinHumansImmunohistochemistryMacrophagesMaleMesenchymal Stem CellsMicrogliaNeuronsRatsRats, Sprague-DawleyDoublecortin Proteincell therapymicrogliastrokeumbilical cord mesenchymal stem cells

Identifiers

PMID29338384
PMCPMC5784525
OpenAlexW2794276273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.