ArticleCancer2018
Nonsurgical premature menopause and reproductive implications in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.
Article in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Possible modification of BRSK1 on the risk of alkylating chemotherapy-related reduced ovarian function.Human reproduction (Oxford, England) · 2021Pooled it
- Female Cardiovascular Health After Childhood Cancer.Current cardiology reports · 2026Review
- Menopausal hormone therapy and comprehensive postmenopausal care in gynecologic cancer survivors: A position paper from the FIGO Committee on Women at Menopausal Age.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Outcomes of adolescents and young adults (AYA) attending for fertility counselling and oocyte cryopreservation prior to gonadotoxic treatment.Journal of assisted reproduction and genetics · 2026Article
- Infertility costs and associated factors in childhood cancer survivors: the role of radiotherapy.Journal of cancer survivorship : research and practice · 2026Article
- Sexual Experience, Psychological Implications, and Typical Response Strategies Among Childhood Cancer Survivors With Sexual Dysfunction in China: A Qualitative Study.Psycho-oncology · 2026Article
- Fertility Preservation Services for Adolescents and Young Adults: 2022 National Cancer Institute Community Oncology Research Program Landscape Assessment.JCO oncology practice · 2026Article
- The value of diffusion-weighted imaging and semi-quantitative dynamic contrast-enhanced MRI in predicting the efficacy of medroxyprogesterone acetate treatment for atypical endometrial hyperplasia and endometrial carcinoma.BMC medical imaging · 2025Article
- Ovarian function in adolescents and young adults undergoing cancer treatment: biochemical and ultrasound marker analysis.Endocrine connections · 2025Article
- Fertility assessment in long-term young female survivors with hematological disease after allogeneic hematopoietic cell transplantation: a single-center real-life cross-sectional study.Annals of hematology · 2025Article
- Ovarian function in female survivors of high-risk neuroblastoma.Pediatric blood & cancer · 2024Article
- Galaxamide alleviates cisplatin-induced premature ovarian insufficiency via the PI3K signaling pathway in HeLa tumor-bearing mice.BMC cancer · 2024Article
- Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway.Scientific reports · 2024Article
- Ovarian Insufficiency and Fertility Preservation During and After Childhood Cancer Treatment.Journal of adolescent and young adult oncology · 2024Review
- Late Adverse Effects after Treatment for Childhood Acute Leukemia.Acta medica academica · 2024Review
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- Development and validation of age-specific risk prediction models for primary ovarian insufficiency in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study and St Jude Lifetime Cohort.The Lancet. Oncology · 2023Article
- Perceived and Objective Fertility Risk Among Female Survivors of Adolescent and Young Adult Cancer.JAMA network open · 2023Article
- Reproductive ability in survivors of childhood, adolescent, and young adult Hodgkin lymphoma: a review.Human reproduction update · 2023Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundSurvivors of childhood cancer are at risk of nonsurgical premature menopause (NSPM). To the authors' knowledge, risk factors for NSPM and its impact on reproduction remain poorly defined.
methodsThe menopausal status of 2930 survivors diagnosed between 1970 and 1986 (median age, 6 years [range, birth-20 years]) who were aged > 18 years at the time of the current study (median age, 35 years [range, 18-58 years]) was compared with 1399 siblings. NSPM was defined as the cessation of menses ≥6 months in duration occurring 5 years after diagnosis and before age 40 that was not due to pregnancy, surgery, or medications. Among survivors, multivariable logistic regression identified risk factors for NSPM. Pregnancy and live birth rates were compared between survivors with and without NSPM.
resultsA total of 110 survivors developed NSPM (median age, 32 years [range, 16-40 years]), with a prevalence at age 40 years of 9.1% (95% confidence interval [95% CI], 4.9%-17.2%); the odds ratio (OR) was 10.5 (95% CI, 4.2-26.3) compared with siblings. Independent risk factors included exposure to a procarbazine dose ≥4000 mg/m
conclusionsSurvivors of childhood cancer are at risk of NSPM associated with lower rates of live birth in their 30s. Those at risk should consider fertility preservation if they anticipate delaying childbearing. Cancer 2018;124:1044-52. © 2018 American Cancer Society.
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