ArticleImmunology2018
Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues.
Article in Immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Thermosensitive Hydrogels for Periodontal Regeneration: A Systematic Review of the Evidence.Clinical and experimental dental research · 2024Pooled it
- Low-replication influenza virus mediates high pathogenicity through an inflammation-driven lung-heart-brain axis in mice.Emerging microbes & infections · 2026Article
- Transcriptomic response to compressive force simulating orthodontic tooth movement in cultured porcine epithelial cell rests of Malassez.Odontology · 2026Article
- Analysis of risk factors for calf muscular vein thrombosis in elderly patients with acute exacerbation of chronic obstructive pulmonary disease.Frontiers in cardiovascular medicine · 2026Article
- Reconstructing the glioblastoma microenvironment in heterotypic 3D spheroids: a multicellular model to study tumor-stromal crosstalk.Frontiers in bioengineering and biotechnology · 2026Article
- Hypoxic Responses in Periodontal Tissues: Influence of Smoking and Periodontitis.Journal of clinical periodontology · 2025Article
- Aging impairs CD8 T cell responses in adoptive T-cell therapy against solid tumors.Frontiers in immunology · 2025Article
- Exploration of the association between HIF3α mRNA and lncRNA MALAT1 in laryngeal squamous cell carcinoma by correlation analysis.Oncology letters · 2024Article
- Article
- Genomics of post-bottleneck recovery in the northern elephant seal.Nature ecology & evolution · 2024Article
- Hypoxia-inducible factor-2α promotes fibrosis in non-alcoholic fatty liver disease by enhancing glutamine catabolism and inhibiting yes-associated protein phosphorylation in hepatic stellate cells.Frontiers in endocrinology · 2024Article
- ACLY promotes gastric tumorigenesis and accelerates peritoneal metastasis of gastric cancer regulated by HIF-1A.Cell cycle (Georgetown, Tex.) · 2023Article
- Langerhans cells shape postnatal oral homeostasis in a mechanical-force-dependent but microbiota and IL17-independent manner.Nature communications · 2023Article
- DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues.Frontiers in oral health · 2023Article
- Bioinformatics analysis of aging-related genes in thoracic aortic aneurysm and dissection.Frontiers in cardiovascular medicine · 2023Article
- Discovering genetic linkage between periodontitis and type 1 diabetes: A bioinformatics study.Frontiers in genetics · 2023Article
- Hypoxia signaling in the equine small intestine: Expression and distribution of hypoxia inducible factors during experimental ischemia.Frontiers in veterinary science · 2023Article
- Article
- A pleiotropic hypoxia-sensitiveScience advances · 2022Article
- Assessment of spatial transcriptomics for oncology discovery.Cell reports methods · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Hypoxia (i.e. oxygen deprivation) activates the hypoxia-signalling pathway, primarily via hypoxia-inducible transcription factors (HIF) for numerous target genes, which mediate angiogenesis, metabolism and coagulation, among other processes to try to replenish tissues with blood and oxygen. Hypoxia signalling dysregulation also commonly occurs during chronic inflammation. We sampled gingival tissues from rhesus monkeys (Macaca mulatta; 3-25 years old) and total RNA was isolated for microarray analysis. HIF1A, HIF1B and HIF2A were significantly different in healthy aged tissues, and both HIF1A and HIF3A were positively correlated with aging. Beyond these transcription factor alterations, analysis of patterns of gene expression involved in hypoxic changes in tissues showed specific increases in metabolic pathway hypoxia-inducible genes, whereas angiogenesis pathway gene changes were more variable in healthy aging tissues across the animals. With periodontitis, aging tissues showed decreases in metabolic gene expression related to carbohydrate/lipid utilization (GBE1, PGAP1, TPI1), energy metabolism and cell cycle regulation (IER3, CCNG2, PER1), with up-regulation of transcription genes and cellular proliferation genes (FOS, EGR1, MET, JMJD6) that are hypoxia-inducible. The potential clinical implications of these results are related to the epidemiological findings of increased susceptibility and expression of periodontitis with aging. More specifically the findings describe that hypoxic stress may exist in aging gingival tissues before documentation of clinical changes of periodontitis and, so, may provide an explanatory molecular risk factor for an elevated capacity of the tissues to express destructive processes in response to changes in the microbial biofilms characteristic of a more pathogenic microbial challenge.
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