ArticlePloS one2018
Hemodynamic characteristics of hyperplastic remodeling lesions in cerebral aneurysms.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review.Neurosurgical review · 2022Pooled it
- Haemodynamic characteristics of thin-walled regions in intracranial aneurysms: intraoperative imaging and CFD analysis.Acta neurochirurgica · 2025Article
- High Middle Cerebral Artery Wall Shear Stress in Branch Atheromatous Disease: A Computational Fluid Dynamics Analysis.Journal of atherosclerosis and thrombosis · 2025Observational
- Fluid structure Interaction analysis for rupture risk assessment in patients with middle cerebral artery aneurysms.Scientific reports · 2025Article
- A Case of a Non-giant Intracranial Aneurysm with Spontaneous Occlusion Directly Observed during Clipping Surgery.NMC case report journal · 2025Article
- Three-dimensional Images Fusion Method Useful for Preoperative Simulation of Clipping Surgery for Cerebral Aneurysms.Neurologia medico-chirurgica · 2024Article
- Article
- Imaging of Intracranial Saccular Aneurysms.Stroke (Hoboken, N.J.) · 2023Review
- Letter to the Relationship of Morphological-Hemodynamic Characteristics, Inflammation, and Remodeling of Aneurysm Wall in Unruptured Intracranial Aneurysms.Translational stroke research · 2023Article
- Aneurysm wall enhancement, hemodynamics, and morphology of intracranial fusiform aneurysms.Frontiers in aging neuroscience · 2023Article
- Hemodynamic Analysis Shows High Wall Shear Stress Is Associated with Intraoperatively Observed Thin Wall Regions of Intracranial Aneurysms.Journal of cardiovascular development and disease · 2022Article
- Prediction of atherosclerotic changes in cavernous carotid aneurysms based on computational fluid dynamics analysis: a proof-of-concept study.Neuroradiology · 2022Article
- Underlying mechanism of hemodynamics and intracranial aneurysm.Chinese neurosurgical journal · 2021Review
- Analysis of Morphological-Hemodynamic Risk Factors for Aneurysm Rupture Including a Newly Introduced Total Volume Ratio.Journal of personalized medicine · 2021Article
- Hemodynamics in aneurysm blebs with different wall characteristics.Journal of neurointerventional surgery · 2021Article
- Article
- Genetic correlates of wall shear stress in a patient-specific 3D-printed cerebral aneurysm model.Journal of neurointerventional surgery · 2019Article
- Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall.AJNR. American journal of neuroradiology · 2019Article
- Combining data from multiple sources to study mechanisms of aneurysm disease: Tools and techniques.International journal for numerical methods in biomedical engineering · 2018Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND & PURPOSE: Hyperplastic remodeling (HR) lesions are sometimes found on cerebral aneurysm walls. Atherosclerosis is the results of HR, which may cause an adverse effect on surgical treatment for cerebral aneurysms. Previous studies have demonstrated that atherosclerotic changes had a correlation with certain hemodynamic characteristics. Therefore, we investigated local hemodynamic characteristics of HR lesions of cerebral aneurysms using computational fluid dynamics (CFD).
methodsTwenty-four cerebral aneurysms were investigated using CFD and intraoperative video recordings. HR lesions and red walls were confirmed on the intraoperative images, and the qualification points were determined on the center of the HR lesions and the red walls. The qualification points were set on the virtual operative images for evaluation of wall shear stress (WSS), normalized WSS (NWSS), oscillatory shear index (OSI), relative residence time (RRT), and aneurysm formation indicator (AFI). These hemodynamic parameters at the qualification points were compared between HR lesions and red walls.
resultsHR lesions had lower NWSS, lower AFI, higher OSI and prolonged RRT compared with red walls. From analysis of the receiver-operating characteristic curve for hemodynamic parameters, OSI was the most optimal hemodynamic parameter to predict HR lesions (area under the curve, 0.745; 95% confidence interval, 0.603-0.887; cutoff value, 0.00917; sensitivity, 0.643; specificity, 0.893; P<0.01). With multivariate logistic regression analyses using stepwise method, NWSS was significantly associated with the HR lesions.
conclusionsAlthough low NWSS was independently associated with HR lesions, OSI is the most valuable hemodynamic parameter to distinguish HR lesions from red walls.
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