ArticlePloS one2018
Menstrual and reproductive factors and risk of breast cancer: A case-control study in the Fez region, Morocco.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Early menarche and breast cancer risk: a systematic review and meta-analysis of 74 case-control studies.Cancer causes & control : CCC · 2026Pooled it
- Long-term health consequences of central precocious/early puberty (CPP) and treatment with Gn-RH analogue: a short update.Acta bio-medica : Atenei Parmensis · 2023Pooled it
- Does marital status correlate with the female breast cancer risk? A systematic review and meta-analysis of observational studies.PloS one · 2020Pooled it
- Assessment of risk factors of breast cancer among women in Dodoma, Tanzania: a community-based cross-sectional study.The Libyan journal of medicine · 2026Article
- Understanding breast cancer causes: insights from Jordanian women's awareness.Future science OA · 2026Article
- The role of body mass index and tumor necrosis factor α in breast cancer development: a case-control study.Archives of medical science : AMS · 2026Article
- Modifiable and Nonmodifiable Risk Factors for Breast Cancer: A Comprehensive Scoping Review.International journal of breast cancer · 2026Review
- Relationship between the risk of breast cancer and periodontal disease: a case-control study.Scientific reports · 2025Article
- Review
- Age at first menstruation and clinical breast cancer screening utilization: insights from the 2021 Côte d'Ivoire demographic and health survey.Reproductive health · 2024Article
- Machine learning techniques to identify risk factors of breast cancer among women in Mashhad, Iran.Journal of preventive medicine and hygiene · 2024Article
- Germline pathogenic variants associated with triple-negative breast cancer in US Hispanic and Guatemalan women using hospital and community-based recruitment strategies.Breast cancer research and treatment · 2024Article
- Comparative analysis of breast cancer characteristics in young premenopausal and postmenopausal women in Ghana.Scientific reports · 2024Article
- BRCA1 and BRCA2 germline mutations in Chinese Hakka breast cancer patients.BMC medical genomics · 2024Article
- Article
- Determinants of breast cancer among women attending oncology units in selected health facilities of Hawassa City, Sidama Region, Southern Ethiopia, 2023: case-control study.Frontiers in oncology · 2024Article
- Protooncogenic Role ofBioMed research international · 2023Article
- The Causal Effect of Reproductive Factors on Breast Cancer: A Two-Sample Mendelian Randomization Study.Journal of clinical medicine · 2023Article
- Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14,731 Patients Diagnosed with Invasive Breast Cancer.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Article
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15 authors.
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Abstract
backgroundBreast cancer is the most common cancer in women worldwide. In the Moroccan context, the role of well-known reproductive factors in breast cancer remains poorly documented. The aim of this study was to explore the relationship between menstrual and reproductive factors and breast cancer risk in Moroccan women in the Fez region.
methodsA case-control study was conducted at the Hassan II University Hospital of Fez between January 2014 and April 2015. A total of 237 cases of breast cancer and 237 age-matched controls were included. Information on sociodemographic characteristics, menstrual and reproductive history, family history of breast cancer, and lifestyle factors was obtained through a structured questionnaire. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals for breast cancer by menstrual and reproductive factors adjusted for potential confounders.
resultsEarly menarche (OR = 1.60, 95% CI: 1.08-2.38) and nulliparity (OR = 3.77, 95% CI: 1.98-7.30) were significantly related to an increased risk of breast cancer, whereas an early age at first full-term pregnancy was associated with a decreased risk of breast cancer (OR = 0.41, 95% CI: 0.25-0.65).
conclusionThe results of this study confirm the role of established reproductive factors for breast cancer in Moroccan women. It identified some susceptible groups at high risk of breast cancer. Preventive interventions and screening should focus on these groups as a priority. These results should be confirmed in a larger, multicenter study.
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