Evidence map›Paper›PMID 29337665›Full record

SynthesisBlood transfusion = Trasfusione del sangue2018

Safety of intravenous tranexamic acid in patients undergoing majororthopaedic surgery: a meta-analysis of randomised controlled trials.

Massimo Franchini, Carlo Mengoli, Marco Marietta, Giuseppe Marano, Stefania Vaglio, Simonetta Pupella, Pier Mannuccio Mannucci, Giancarlo M Liumbruno

Registry-linked trialOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Blood transfusion = Trasfusione del sangue, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05802238 (Efficacy of Tranexamic Acid), which is not on this map. Cited by 54 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 10 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05802238 phase2withdrawnnot on this mapstarted 2023, after this paper: background citation

Efficacy of Tranexamic Acid (TXA) in Humerus ORIF

TypeinterventionalSponsorAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)Ran2023 to 2024Enrolled0ConditionsFracture HumerusArmsTranexamic acid (TXA), Saline
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 10 syntheses or guidelines pooled it, 111 citations in OpenAlex.

  1. Tranexamic acid for percutaneous nephrolithotomy.The Cochrane database of systematic reviews · 2023
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  15. [Comparison of combined intravenous and topical use of tranexamic acid with different dosage in primary total knee arthroplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Massimo FranchiniItalian National Blood Centre, National Institute of Health, Rome, Italy.
Carlo MengoliItalian National Blood Centre, National Institute of Health, Rome, Italy.
Marco MariettaDepartment of Oncology, Haematology and Respiratory Diseases, University Hospital, Modena, Italy.
Giuseppe MaranoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Stefania VaglioItalian National Blood Centre, National Institute of Health, Rome, Italy.
Simonetta PupellaItalian National Blood Centre, National Institute of Health, Rome, Italy.
Pier Mannuccio MannucciScientific Direction, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.
Giancarlo M LiumbrunoItalian National Blood Centre, National Institute of Health, Rome, Italy.
Azienda Ospedaliera Carlo Poma · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the various pharmacological options to decrease peri-operative bleeding, tranexamic acid appears to be one of the most interesting. Several trials have consistently documented the efficacy of this synthetic drug in reducing the risk of blood loss and the need for allogeneic blood transfusion in patients undergoing total hip and knee arthroplasty. The safety of intravenous tranexamic acid in major orthopaedic surgery, particularly regarding the risk of venous thromboembolism, was systematically analysed in this review. A systematic search of the literature identified 73 randomised controlled trials involving 4,174 patients and 2,779 controls. The raw overall incidence of venous thromboembolism was 2.1% in patients who received intravenous tranexamic acid and 2.0% in controls. A meta-analytic pooling showed that the risk of venous thromboembolism in tranexamic acid-treated patients was not significantly different from that of controls (risk difference: 0.01%, 95% confidence interval [CI]: -0.05%, 0.07%; risk ratio: 1.067, 95% CI: 0.760-1.496). Other severe drug-related adverse events occurred very rarely (0.1%). In conclusion, the results of this systematic review and meta-analysis show that intravenous tranexamic acid is a safe pharmacological treatment to reduce blood loss and transfusion requirements in patients undergoing major orthopaedic surgery.

Indexed as

Orthopedic ProceduresVenous ThromboembolismAdministration, IntravenousBlood Loss, SurgicalFemaleHumansMaleRandomized Controlled Trials as TopicRisk FactorsTranexamic AcidTranexamic Acid

Identifiers

PMID29337665
PMCPMC5770313
OpenAlexW2802943544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.