Evidence map›Paper›PMID 29337651›Full record

ArticleHuman vaccines & immunotherapeutics2018

The effects of booster vaccination of hepatitis B vaccine on children 5-15 years after primary immunization: A 5-year follow-up study.

Zikang Wu, Jun Yao, Hongdan Bao, Yongdi Chen, Shunshun Lu, Jing Li, Linna Yang, Zhenggang Jiang, Jingjing Ren, Kai-Jin Xu and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Zikang Wua School of Medicine , Ningbo University , Ningbo , Zhejiang , China.
Jun Yaob The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Hongdan Baoa School of Medicine , Ningbo University , Ningbo , Zhejiang , China.
Yongdi Chenb The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Shunshun Luc Ningbo Medical Center Lihuili Eastern Hospital , Ningbo , Zhejiang , China.
Jing Lid Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
Linna Yangd Zhejiang Provincial Hospital , Hangzhou , Zhejiang , China.
Zhenggang Jiangb The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Jingjing Rene State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Kai-Jin Xue State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Bing Ruane State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Shi-Gui Yange State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Tian-Sheng Xiee State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Key Laboratory of Infectious Diseases, the First Affiliated Hospital , School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
Qian Lib The National Science and Technology Project , Zhejiang Provincial Center for Disease Control and Prevention , Hangzhou , Zhejiang , China.
Zhejiang Center for Disease Control and Prevention · CNZhejiang University · CNNingbo University · CNNingbo Medical Center Lihuili Hospital · CNState Key Laboratory of Diagnosis and Treatment of Infectious Diseases

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate changes in hepatitis B surface antibody titers (anti-HBs) after booster vaccinations in children aged 5-15 y and to provide suitable immunization strategies. A total of 2208 children were initially enrolled in screening, and 559 children were finally included. The participants were divided into 2 groups according to their pre-booster anti-HBs levels: Group I, <10 mIU/ml and Group II, ≥10 mIU/ml. Group I was administered 3 doses of booster hepatitis B vaccine (0-1-6 months, 10 μg), and Group II was administered 1 dose of booster hepatitis B vaccine (10 μg). The antibody titer changes were examined at 4 time points: 1 month after dose 1 and dose 3, and 1 year and 5 years after dose 3. The protective seroconversion rates at those points were 95.65%, 99.67%, 97.59% and 91.05% (p < 0.001), respectively, in Group I, and 100.00%, 99.87%, 99.66% and 98.21% (χ

Indexed as

AdolescentAge FactorsChildFemaleFollow-Up StudiesHepatitis BHepatitis B AntibodiesHepatitis B VaccinesHepatitis B virusHumansImmunization, SecondaryImmunologic MemoryMaleSeroconversionVaccinationHepatitis B AntibodiesHepatitis B Vaccinesanti-HBsbooster vaccinationchildrenfollow-upHepatitis B virus (HBV)vaccine

Identifiers

PMID29337651
PMCPMC5989910
OpenAlexW2784288927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.