Evidence map›Paper›PMID 29337245›Full record

ArticleExperimental and molecular pathology2018

Hepatic alcohol dehydrogenase deficiency induces pancreatic injury in chronic ethanol feeding model of deer mice.

Samir M Amer, Kamlesh K Bhopale, Ramu D Kakumanu, Vsevolod L Popov, Bill A Rampy, Inas H El-Mehallawi, Magdy M Ashmawy, G A Shakeel Ansari, Bhupendra S Kaphalia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and molecular pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Samir M AmerDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA; Department of Forensic Medicine and Clinical Toxicology, Tanta University, Tanta, Egypt.
Kamlesh K BhopaleDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Ramu D KakumanuDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Vsevolod L PopovDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Bill A RampyDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Inas H El-MehallawiDepartment of Forensic Medicine and Clinical Toxicology, Tanta University, Tanta, Egypt.
Magdy M AshmawyDepartment of Forensic Medicine and Clinical Toxicology, Tanta University, Tanta, Egypt.
G A Shakeel AnsariDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Bhupendra S KaphaliaDepartment of Pathology, The University of Texas Medical Branch, Galveston, TX 77555, USA. Electronic address: bkaphali@utmb.edu.
The University of Texas Medical Branch at Galveston · USTanta University · EG

Funding

Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7M
Role of Alcohol Metabolism in Alcoholic Chronic PancreatitisR01AA025850 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAPHALIA, BHUPENDRA S · 2017 to 2021
$1.7M
AMPK Signaling and Chronic Alcoholic PancreatitisR21AA024699 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAPHALIA, BHUPENDRA S · 2016 to 2017
$407k
NIAAA NIH HHS R01 AA025850NIAAA NIH HHS R21 AA024699NIEHS NIH HHS P30 ES006676
6 · The paper itself

Abstract

The single most common cause of chronic pancreatitis (CP, a serious inflammatory disease) is chronic alcohol abuse, which impairs hepatic alcohol dehydrogenase (ADH, a major ethanol oxidizing enzyme). Previously, we found ~5 fold greater fatty acid ethyl esters (FAEEs), and injury in the pancreas of hepatic ADH deficient (ADH

Indexed as

Alcohol DehydrogenaseAlcoholismAnimalsBlood Alcohol ContentDisease Models, AnimalEndoplasmic ReticulumEndoplasmic Reticulum StressEthanolEthyl EthersFatty AcidsLiverMicePancreasPeromyscusAlcohol DehydrogenaseBlood Alcohol ContentEthanolEthyl EthersFatty AcidsAlcohol dehydrogenaseAlcoholic chronic pancreatitisDeer miceER membrane stressEthanolFatty acid ethyl esters

Identifiers

PMID29337245
PMCPMC5801077
OpenAlexW2783006000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.