Evidence map›Paper›PMID 29337233›Full record

ArticleNeuroscience2018

Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice.

Xiaolu Tang, Luyan Jiao, Meige Zheng, Yan Yan, Qi Nie, Ting Wu, Xiaomei Wan, Guofeng Zhang, Yonglin Li, Song Wu and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Tau knockout exacerbates degeneration of parvalbumin-positive neurons in substantia nigra pars reticulata in Parkinson's disease-related α-synuclein A53T mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Xiaolu TangGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Luyan JiaoGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Meige ZhengGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Yan YanGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Qi NieGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Ting WuGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Xiaomei WanGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Guofeng ZhangGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Yonglin LiGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Song WuGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Bin JiangGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China.
Huaibin CaiTransgenics Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA.
Pingyi XuDepartment of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangdong 510120, China. Electronic address: pingyixujd@163.com.
Jinhai DuanDepartment of Neurology & Guangdong Institute of Geriatrics, Guangdong General Hospital, #106, Zhongshan 2nd Road, Guanzhou 510080, China. Electronic address: 2694178595@qq.com.
Xian LinGuangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China; Department of Anatomy & Research Center for Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, #74, Zhongshan 2nd Road, Guangzhou 510080, China. Electronic address: linxian3@mail.sysu.edu.cn.
Sun Yat-sen University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNGuangdong General Hospital · CNNational Institutes of Health · US

Funding

Pathobiological Studies of Neurodegenerative DiseasesZ01AG000959 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2004 to 2008
$1.7M
Intramural NIH HHS Z01 AG000959
6 · The paper itself

Abstract

Tau protein participates in microtubule stabilization, axonal transport, and protein trafficking. Loss of normal tau function will exert a negative effect. However, current knowledge on the impact of tau deficiency on the motor behavior and related neurobiological changes is controversial. In this study, we examined motor functions and analyzed several proteins implicated in the maintenance of midbrain dopaminergic (DA) neurons (mDANs) function of adult and aged tau

Indexed as

AgingAnimalsBiomechanical PhenomenaDisease Models, AnimalDopamine Plasma Membrane Transport ProteinsDopaminergic NeuronsDown-RegulationG Protein-Coupled Inwardly-Rectifying Potassium ChannelsMaleMice, Inbred C57BLMice, TransgenicMotor ActivityMuscle StrengthOtx Transcription FactorsParkinsonian Disorderstau ProteinsDopamine Plasma Membrane Transport ProteinsG Protein-Coupled Inwardly-Rectifying Potassium ChannelsKcnj6 protein, mouseMapt protein, mouseOtx2 protein, mouseOtx Transcription Factorstau Proteinsdopaminergic neuronmidbrainorthodenticle homeobox 2tau deficiency

Identifiers

PMID29337233
PMCPMC5819331
OpenAlexW2784035040

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.