ArticleStem cell reports2018
Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells.
Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Engineered thoracic spinal cord organoids for transplantation after spinal cord injury.Nature biomedical engineering · 2026Article
- A controllable human spinal cord model with full dorsoventral patterning.Nature communications · 2026Article
- A modular silk-collagen scaffold to model dorsoventral spinal cord organization using human pluripotent stem cells.Journal of materials chemistry. B · 2026Article
- Article
- Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury.Neural regeneration research · 2025Article
- Human microphysiological model of dorsal root ganglion-spinal cord dorsal horn circuitry recapitulates opioid induced effects.bioRxiv : the preprint server for biology · 2025Article
- 3D-Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury.Advanced healthcare materials · 2025Article
- Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling.Cell reports · 2024Article
- Generation of self-renewing neuromesodermal progenitors with neuronal and skeletal muscle bipotential from human embryonic stem cells.Cell reports methods · 2024Article
- Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses.Development (Cambridge, England) · 2024Article
- BMPRIINeural regeneration research · 2024Article
- A novel protocol to derive cervical motor neurons from induced pluripotent stem cells for amyotrophic lateral sclerosis.Stem cell reports · 2023Article
- Neuroplasticity and regeneration after spinal cord injury.North American Spine Society journal · 2023Article
- Review
- Accelerated differentiation of human induced pluripotent stem cells into regionally specific dorsal and ventral spinal neural progenitor cells for application in spinal cord therapeutics.Frontiers in neuroscience · 2023Article
- Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns.Science advances · 2022Article
- In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion.Cell reports · 2022Article
- Article
- Innovations and advances in modelling and measuring pain in animals.Nature reviews. Neuroscience · 2022Review
- Cell transplantation to repair the injured spinal cord.International review of neurobiology · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Cellular replacement therapies for neurological conditions use human embryonic stem cell (hESC)- or induced pluripotent stem cell (hiPSC)-derived neurons to replace damaged or diseased populations of neurons. For the spinal cord, significant progress has been made generating the in-vitro-derived motor neurons required to restore coordinated movement. However, there is as yet no protocol to generate in-vitro-derived sensory interneurons (INs), which permit perception of the environment. Here, we report on the development of a directed differentiation protocol to derive sensory INs for both hESCs and hiPSCs. Two developmentally relevant factors, retinoic acid in combination with bone morphogenetic protein 4, can be used to generate three classes of sensory INs: the proprioceptive dI1s, the dI2s, and mechanosensory dI3s. Critical to this protocol is the competence state of the neural progenitors, which changes over time. This protocol will facilitate developing cellular replacement therapies to reestablish sensory connections in injured patients.
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Registered trials
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