ArticleVaccine2018
A novel inactivated vaccine against Lawsonia intracellularis induces rapid induction of humoral immunity, reduction of bacterial shedding and provides robust gut barrier function.
Article in Vaccine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Efficiency of Commercial and Test Vaccines Against Lawsonia intracellularis on Clinical and Immunological Parameters in Swine: A Systematic Review.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Pooled it
- Design and functional characterization of recombinant chimeras as vaccine candidates against Lawsonia intracellularis.Biotechnology letters · 2026Article
- Immune Response of Pigs Vaccinated Against Proliferative Enteropathy and Co-Infected withAnimals : an open access journal from MDPI · 2025Article
- Article
- Article
- Outer Membrane Proteins as Vaccine Targets AgainstVaccines · 2025Article
- Vaccination versus antimicrobials to prevent Porcine Proliferative Enteropathy: associated costs and effects on piglets' growth, health, and serological performance.Frontiers in veterinary science · 2025Article
- Well-Being and Performance of Nursery Pigs Subjected to Different Commercial Vaccines Against Porcine Circovirus Type 2,Vaccines · 2024Article
- Article
- New Formulation of a Subunit Vaccine Candidate againstVaccines · 2023Article
- Alleviative Effect of Probiotic Ferment onBiology · 2023Article
- Development and validation of a flow cytometry antibody test forFrontiers in immunology · 2023Article
- The Effectiveness of Commercial Vaccination againstVeterinary sciences · 2022Review
- In Vitro Screening of Non-Antibiotic Components to Mitigate Intestinal Lesions Caused byAnimals : an open access journal from MDPI · 2022Article
- Characterisation of autophagy disruption in the ileum of pigs infected with Lawsonia intracellularis.Veterinary research communications · 2022Article
- Probiotics mediated gut microbiota diversity shifts are associated with reduction in histopathology and shedding of Lawsonia intracellularis.Animal microbiome · 2021Article
- Preparation and Characterization of a New Monoclonal Antibody Specific AgainstFrontiers in veterinary science · 2021Article
- Evaluation of swine enteroids as in vitro models for Lawsonia intracellularis infection1,2.Journal of animal science · 2020Article
- Efficacy of a novel intradermalPorcine health management · 2020Article
- Bacillus pumilus probiotic feed supplementation mitigates Lawsonia intracellularis shedding and lesions.Veterinary research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Porcine proliferative ileitis is a major economic burden for the swine industry, affecting growing pigs and young adult pigs. In this study, the protective efficacy of an inactivated, injectable whole-cell bacteria vaccine against L. intracellularis - Porcilis® Ileitis was evaluated under field conditions. Eighty-five, three-week-old pigs on a commercial farrow-to-finish farm were vaccinated by the intramuscular route, either with a dose of injectable vaccine, or with saline. A subset of vaccinates and control pigs were necropsied at 21 days post-challenge. Incidence and severity of ileitis were evaluated by gross and microscopic observation of ileal tissues. Colonization of the gut after challenge was examined by L. intracellularis-specific immunohistochemistry, and qPCR of ileal scrapings. Integrity of the intestinal barrier was evaluated to quantify a range of intestinal markers including secreted mucin and intestinal alkaline phosphatase, and innate immune markers including Caspase-3 and Calprotectin. A second subset of pigs was monitored for fecal shedding of L. intracellularis, until resolution of shedding. Our investigation indicated that Porcilis Ileitis provided robust protection against ileitis, reduced bacterial shedding 15-fold (p < .05) and preserved normal gut barrier function in the face of an experimental challenge with virulent L. intracellularis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.