ArticleJournal of mass spectrometry : JMS2018
Identification and quantification of VOCs by proton transfer reaction time of flight mass spectrometry: An experimental workflow for the optimization of specificity, sensitivity, and accuracy.
Article in Journal of mass spectrometry : JMS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 51 citations in OpenAlex.
- Odour Profiling for Animal Management and Behavioural Manipulation: An Overview of the Tools and Applications.Journal of chemical ecology · 2026Review
- Early Postoperative Remodeling of the Exhaled Volatilome Following Curative Surgery for Colorectal Cancer.Journal of clinical medicine · 2026Article
- Cross-Disease Breathomics by PTR-TOF-MS: Multiclass Machine Learning and Network Remodeling Across Asthma, COPD, Cystic Fibrosis, and Lymphangioleiomyomatosis.International journal of molecular sciences · 2026Article
- The human volatilome meets cancer diagnostics: past, present, and future of noninvasive applications.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research.Analytical and bioanalytical chemistry · 2024Article
- A matrix-centered view of mass spectrometry platform innovation for volatilome research.Frontiers in molecular biosciences · 2024Review
- Abiotic Stress and Belowground Microbiome: The Potential of Omics Approaches.International journal of molecular sciences · 2022Review
- Real-Time Non-Invasive Monitoring of Short-Chain Fatty Acids in Exhaled Breath.Frontiers in chemistry · 2022Article
- Identifying volatile in vitro biomarkers for oral bacteria with proton-transfer-reaction mass spectrometry and gas chromatography-mass spectrometry.Scientific reports · 2021Article
- Feasibility and acceptability of breath research in primary care: a prospective, cross-sectional, observational study.BMJ open · 2021Observational
- Endogenous aldehyde accumulation generates genotoxicity and exhaled biomarkers in esophageal adenocarcinoma.Nature communications · 2021Article
- Identification and quantification of VOCs by proton transfer reaction time of flight mass spectrometry: An experimental workflow for the optimization of specificity, sensitivity, and accuracy.Journal of mass spectrometry : JMS · 2018Article
- Article
- Analysis of volatile fraction of sweetie (Monatshefte fur chemie · 2018Article
- Measuring volatile emissions from moss gametophytes: A review of methodologies and new applications.Applications in plant sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proton transfer reaction time of flight mass spectrometry (PTR-ToF-MS) is a direct injection MS technique, allowing for the sensitive and real-time detection, identification, and quantification of volatile organic compounds. When aiming to employ PTR-ToF-MS for targeted volatile organic compound analysis, some methodological questions must be addressed, such as the need to correctly identify product ions, or evaluating the quantitation accuracy. This work proposes a workflow for PTR-ToF-MS method development, addressing the main issues affecting the reliable identification and quantification of target compounds. We determined the fragmentation patterns of 13 selected compounds (aldehydes, fatty acids, phenols). Experiments were conducted under breath-relevant conditions (100% humid air), and within an extended range of reduced electric field values (E/N = 48-144 Td), obtained by changing drift tube voltage. Reactivity was inspected using H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.