ArticleHIV medicine2018
National audit of perinatal HIV infections in the UK, 2006-2013: what lessons can be learnt?
Article in HIV medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Interventions to improve antiretroviral adherence in HIV-infected pregnant women: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Raltegravir versus efavirenz in antiretroviral-naive pregnant women living with HIV (NICHD P1081): an open-label, randomised, controlled, phase 4 trial.The lancet. HIV · 2020Trial
- Perinatal HIV in Europe: Clinical Advances and Psychosocial Challenges-A Scoping Review.Tropical medicine and infectious disease · 2026Review
- Update on HIV prevention and management in pregnancy Number 10 - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Bictegravir Use During Pregnancy: A Multicenter Retrospective Analysis Evaluating HIV Viral Suppression and Perinatal Outcomes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- How women living with HIV in the UK manage infant-feeding decisions and vertical transmission risk - a qualitative study.BMC public health · 2024Article
- Challenges, risks, and opportunities of antiretroviral drugs in women of reproductive potential.Expert review of anti-infective therapy · 2024Review
- HIV seroconversion during pregnancy: paediatric recurrent candidiasis - a clue for diagnosis.BMJ case reports · 2024Article
- "We decided together": a qualitative study about women with HIV navigating infant-feeding decisions with the father of their children.BMC pregnancy and childbirth · 2024Article
- Trends in management and outcomes of pregnant women living with HIV between 2008-2013 and 2014-2019: A retrospective cohort study.Frontiers in medicine · 2022Article
- Trends in undiagnosed HIV prevalence in England and implications for eliminating HIV transmission by 2030: an evidence synthesis model.The Lancet. Public health · 2021Article
- HIV-1 infection among women in Israel, 2010-2018.BMC infectious diseases · 2020Article
- HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE.EClinicalMedicine · 2020Article
- Article
- Antenatal HIV screening: results from the National Perinatal Survey, France, 2016.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Point-of-care HIV testing best practice for early infant diagnosis: an implementation study.BMC public health · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe aim of the study was to investigate circumstances surrounding perinatal transmissions of HIV (PHIVs) in the UK.
methodsThe National Study of HIV in Pregnancy and Childhood conducts comprehensive surveillance of all pregnancies in women diagnosed with HIV infection and their infants in the UK; reports of all HIV-diagnosed children are also sought, regardless of country of birth. Children with PHIV born in 2006-2013 and reported by 2014 were included in an audit, with additional data collection via telephone interviews with clinicians involved in each case. Contributing factors for each transmission were identified, and cases described according to main likely contributing factor, by maternal diagnosis timing.
resultsA total of 108 PHIVs were identified. Of the 41 (38%) infants whose mothers were diagnosed before delivery, it is probable that most were infected in utero, around 20% intrapartum and 20% through breastfeeding. Timing of transmission was unknown for most children of undiagnosed mothers. For infants born to diagnosed women, the most common contributing factors for transmission were difficulties with engagement and/or antiretroviral therapy (ART) adherence in pregnancy (14 of 41) and late antenatal booking (nine of 41); for the 67 children with undiagnosed mothers, these were decline of HIV testing (28 of 67) and seroconversion (23 of 67). Adverse social circumstances around the time of pregnancy were reported for 53% of women, including uncertain immigration status, housing problems and intimate partner violence. Eight children died, all born to undiagnosed mothers.
conclusionsPriority areas requiring improvement include reducing incident infections, improving ART adherence and facilitating better engagement in care, with attention to addressing the health inequalities and adverse social situations faced by these women.
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