ArticleChinese medical journal2018
Early Neurological Deterioration after Recanalization Treatment in Patients with Acute Ischemic Stroke: A Retrospective Study.
Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Early neurological deterioration as a predictor of outcomes after endovascular thrombectomy for stroke: A systematic review and meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Pooled it
- Association of Blood Pressure With Outcomes in Acute Stroke Thrombectomy.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- Impact of Prestroke Antiplatelet Therapy on the Efficacy of Intravenous Tirofiban at Preventing Early Neurological Deterioration: A Prespecified Subgroup Analysis of the TREND Trial.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Trial
- Baseline systolic blood pressure and efficacy of dual antiplatelet in acute ischaemic stroke.Stroke and vascular neurology · 2025Trial
- Detection of early neurological deterioration using a quantitative electroencephalography system in patients with large vessel occlusion stroke after endovascular treatment.Journal of neurointerventional surgery · 2025Trial
- Enhanced versus standard hydration in acute ischemic stroke: REVIVE-A randomized clinical trial.International journal of stroke : official journal of the International Stroke Society · 2024Trial
- Systolic blood pressure and early neurological deterioration in minor stroke: A post hoc analysis of ARAMIS trial.CNS neuroscience & therapeutics · 2024Trial
- Combined ipsilateral peak systolic velocity and ASPECTS are associated with early neurological deterioration after endovascular thrombectomy: a prospective cohort study.BMC neurology · 2026Article
- Exosomal Protein Biomarkers for Predicting Early Neurological Deterioration Following Intravenous Thrombolysis in Acute Ischemic Stroke.Translational stroke research · 2026Article
- Letter to the editor regarding "Early neurological deterioration after endovascular treatment for acute stroke with mild symptoms".Neuroradiology · 2025Article
- Baseline ASPECTS predicts early neurological deterioration and functional outcomes after endovascular thrombectomy in acute ischemic stroke.Frontiers in neurology · 2025Article
- Hyperperfusion Syndrome Following Tissue Plasminogen Activator Administration: A Case Report with Radiological Evidence.Journal of the Korean Society of Radiology · 2024Article
- Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow.European stroke journal · 2024Article
- Article
- Correlation between triglyceride-glucose index and early neurological deterioration in patients with acute mild ischemic stroke.Frontiers in neurology · 2024Article
- Application of a nomogram model for the prediction of 90-day poor outcomes following mechanical thrombectomy in patients with acute anterior circulation large-vessel occlusion.Frontiers in neurology · 2024Article
- Prediction of early neurological deterioration in acute ischemic stroke patients treated with intravenous thrombolysis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Association of triglyceride-glucose index with early neurological deterioration events in patients with acute ischemic stroke.Diabetology & metabolic syndrome · 2023Article
- CNS-LAND score: predicting early neurological deterioration after intravenous thrombolysis based on systemic responses and injury.Frontiers in neurology · 2023Article
- Nomogram model of functional outcome for endovascular treatment in patients with acute basilar artery occlusion.Frontiers in neurology · 2023Article
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6 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundEarly neurological deterioration (END) is a prominent issue after recanalization treatment. However, few studies have reported the characteristics of END after endovascular treatment (EVT) as so far. This study investigated the incidence, composition, and outcomes of END after intravenous recombinant tissue plasminogen activator (IV rt-PA) and EVT of acute ischemic stroke, and identified risk factors for END.
methodsMedical records of patients who received recanalization treatment between January 1, 2014, and December 31, 2015 were reviewed. Patients were classified into IV rt-PA or EVT group according to the methods of recanalization treatment. The END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) ≥4 or an increase in Ia of NIHSS ≥1 within 72 h after recanalization treatment. Clinical data were compared between the END and non-END subgroups within each recanalization group.
resultsOf the 278 patients included in the study, the incidence of END was 34.2%. The incidence rates of END were 29.8% in the IV rt-PA group and 40.2% in the EVT group. Ischemia progression (68.4%) was the main contributor to END followed by vasogenic cerebral edema (21.1%) and symptomatic intracranial hemorrhage (10.5%). Multivariate logistic regression showed that admission systolic blood pressure (SBP) ≥160 mmHg (odds ratio [OR]: 2.312, 95% confidence interval [CI]: 1.105-4.837) and large artery occlusion after IV rt-PA (OR: 3.628, 95% CI: 1.482-8.881) independently predicted END after IV rt-PA; and admission SBP ≥140 mmHg (OR: 5.183, 95% CI: 1.967-13.661), partial recanalization (OR: 4.791, 95% CI: 1.749-13.121), and nonrecanalization (OR: 5.952, 95% CI: 1.841-19.243) independently predicted END after EVT. The mortality rate and grave outcome rate at discharge of all the END patients (26.3% and 55.8%) were higher than those of all the non-END patients (1.1% and 18.6%; P < 0.01).
conclusionsEND was not an uncommon event and associated with death and grave outcome at discharge. High admission SBP and unsatisfactory recanalization of occluded arteries might predict END.
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