ArticleEpilepsia2018
Sudden unexpected death in epilepsy in patients treated with brain-responsive neurostimulation.
Article in Epilepsia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- Cardiorespiratory cross-frequency coupling biomarker for sudden unexpected death in epilepsy.Epilepsia · 2026Article
- Safety of Intracranial Neuromodulation in Drug-Resistant Pediatric and Adult Epilepsy.Neurology · 2026Article
- sEEG-guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode-mediated neuromodulation.Epilepsia open · 2026Article
- Current practices and trends in surgical decision-making for children with Lennox-Gastaut syndrome: A cross-sectional survey by the Pediatric Epilepsy Research Consortium.Epilepsia open · 2025Article
- Potential for Therapeutic Alteration of the Underlying Biology of Epilepsy.Biomedicines · 2025Review
- Sudden Unexpected Death in Epilepsy: A Narrative Review of Mechanism, Risks, and Prevention.Journal of clinical medicine · 2025Review
- Utilizing thalamic deep brain stimulation for an electronic seizure diary in a definite sudden unexpected death in epilepsy case.Annals of clinical and translational neurology · 2024Article
- Sudden unexpected death in epilepsy in a patient with a brain-responsive neurostimulation device.Annals of the Child Neurology Society · 2024Article
- Arousal and salience network connectivity alterations in surgical temporal lobe epilepsy.Journal of neurosurgery · 2023Article
- Association Between Standardized Mortality Ratio and Utilization of Care in US Veterans With Drug-Resistant Epilepsy Compared With All US Veterans and the US General Population.JAMA neurology · 2022Observational
- The Interaction Between Sleep and Epilepsy.Current neurology and neuroscience reports · 2022Review
- Sudden Unexpected Death in Epilepsy.Neurology international · 2022Review
- Sudden Unexpected Death in Epilepsy (SUDEP): How Do We Prevent This Childhood Tragedy?The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- Cheers for SANTĖ: Long Term Safety and Efficacy of Anterior Nucleus of the Thalamus DBS.Epilepsy currents · 2021Article
- Article
- Responsive Neurostimulation as a Novel Palliative Option in Epilepsy Surgery.Neurologia medico-chirurgica · 2021Review
- Centromedian thalamic responsive neurostimulation for Lennox-Gastaut epilepsy and autism.Annals of clinical and translational neurology · 2020Article
- Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.Neurology · 2020Article
- All-cause mortality and SUDEP in a surgical epilepsy population.Epilepsy & behavior : E&B · 2020Article
- How technology is driving the landscape of epilepsy surgery.Epilepsia · 2020Review
Corrections and comments
- Commented on by
Authors and funding
8 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the incidence and clinical features of sudden unexpected death in epilepsy (SUDEP) in patients treated with direct brain-responsive stimulation with the RNS System.
methodsAll deaths in patients treated in clinical trials (N = 256) or following U.S. Food and Drug Administration (FDA) approval (N = 451) through May 5, 2016, were adjudicated for SUDEP.
resultsThere were 14 deaths among 707 patients (2208 postimplantation years), including 2 possible, 1 probable, and 4 definite SUDEP events. The rate of probable or definite SUDEP was 2.0/1000 (95% confidence interval [CI] 0.7-5.2) over 2036 patient stimulation years and 2.3/1000 (95% CI 0.9-5.4) over 2208 patient implant years. Stored electrocorticograms around the time of death were available for 4 patients with probable/definite SUDEP and revealed the following: frequent epileptiform activity ending abruptly (n = 2), no epileptiform activity or seizures (n = 1), and an electrographic and witnessed seizure with cessation of postictal electrocorticography (ECoG) activity associated with apnea and pulselessness (n = 1). SIGNIFICANCE: The SUDEP rate of 2.0/1000 patient stimulation years among patients treated with the RNS System is favorable relative to treatment-resistant epilepsy patients randomized to the placebo arm of add-on drug studies or with seizures after resective surgery. Our findings support that treatments that reduce seizures reduce SUDEP risk and that not all SUDEPs follow seizures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.