Evidence map›Paper›PMID 29335889›Full record

ArticleThe journal of headache and pain2018

Comparison of gray matter volume between migraine and "strict-criteria" tension-type headache.

Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin, Shuu-Jiun Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Wei-Ta ChenDepartment of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan. wtchen@vghtpe.gov.tw.ORCID http://orcid.org/0000-0003-2355-3540
Kun-Hsien ChouBrain Research Center, National Yang-Ming University, Taipei, Taiwan.
Pei-Lin LeeDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.
Fu-Jung HsiaoBrain Research Center, National Yang-Ming University, Taipei, Taiwan.
David M NiddamBrain Research Center, National Yang-Ming University, Taipei, Taiwan.
Kuan-Lin LaiDepartment of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Jong-Ling FuhDepartment of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Ching-Po LinBrain Research Center, National Yang-Ming University, Taipei, Taiwan.
Shuu-Jiun WangDepartment of Neurology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

Ministry of Science and Technology, Taiwan 103-2321-B-010-017, 102-2321-B-010-030, 100-2314-B-010-018-MY3, 104-2745-B-010-003 and MOST 106-2321-B-010-009Ministry of Science and Technology, Taiwan NSC101-2314-B-075-068-MY2, MOST 106-2321-B-010-009-, and MOST 106-2314-B-075-026-Taipei Veterans General Hospital V105C-092, V105E9-005-MY2-1, and VGHUST104-G7-1-3Taipei Veterans General Hospital VGHUST105-G7-1-1, V105C-127, V105E9-001-MY2-1, and VTA105-V1-1-1
6 · The paper itself

Abstract

backgroundDespite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both types of headaches are similar in brain morphology.

methodsConsecutive patients with TTH and age- and sex-matched patients with migraine and healthy controls were enrolled for brain magnetic resonance imaging examination. Patients with TTH were excluded if they reported any headache features or associated symptoms of migraine. Changes in gray matter (GM) volume associated with headache diagnosis (TTH vs. migraine) and frequency (episodic vs. chronic) were examined using voxel-based morphometry. The correlation with headache profile and the discriminative ability between TTH and migraine were also investigated for these GM changes.

resultsIn comparison with controls (n = 43), the patients with TTH (25 episodic and 24 chronic) exhibited a GM volume increase in the anterior cingulate cortex, supramarginal gyrus, temporal pole, lateral occipital cortex, and caudate. The patients with migraine (31 episodic and 25 chronic) conversely exhibited a GM volume decrease in the orbitofrontal cortex. These GM changes did not correlate with any headache profile. A voxel-wise 2 × 2 factorial analysis further revealed the substantial effects of headache types and frequency in the comparison of GM volume between TTH and migraine. Specifically, the migraine group (vs. TTH) had a GM decrease in the superior and middle frontal gyri, cerebellum, dorsal striatum, and precuneus. The chronic group (vs. episodic group) otherwise demonstrated a GM decrease in the bilateral insula and anterior cingulate cortex. In receiver operating characteristic analysis, the GM volumes of the left superior frontal gyrus and right cerebellum V combined had good discriminative ability for distinguishing TTH and migraine (area under the curve = 0.806).

conclusionsTTH and migraine are separate headache disorders with different characteristics in relation to GM changes. The major morphological difference between the two types of headaches is the relative GM decrease of the prefrontal and cerebellar regions in migraine, which may reflect a higher allostatic load associated with this disabling headache.

Indexed as

AdultFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedMigraine DisordersTension-Type HeadacheYoung AdultGray matterMagnetic resonance imaging (MRI)MigraineTension-type headacheVoxel-based morphometry

Identifiers

PMID29335889
PMCPMC5768588
OpenAlexW2783091296

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.