Evidence map›Paper›PMID 29335880›Full record

ArticlePediatric radiology2018

The long-term effect of erythropoiesis stimulating agents given to preterm infants: a proton magnetic resonance spectroscopy study on neurometabolites in early childhood.

Charles Gasparovic, Arvind Caprihan, Ronald A Yeo, John Phillips, Jean R Lowe, Richard Campbell, Robin K Ohls

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Charles GasparovicMind Research Network, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.ORCID 0000-0002-4433-7815
Arvind CaprihanMind Research Network, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ronald A YeoDepartment of Psychology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
John PhillipsMind Research Network, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Jean R LoweDepartment of Pediatrics, MSC10 5590, 1 University of New Mexico, Albuquerque, NM, 87131-0001, USA.
Richard CampbellPsychiatry and Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Robin K OhlsDepartment of Pediatrics, MSC10 5590, 1 University of New Mexico, Albuquerque, NM, 87131-0001, USA. rohls@salud.unm.edu.
University of New Mexico · USMind Research Network · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain imaging and developmental follow-up of infants treated with erythropoietinR01HD059856 · NICHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI OHLS, ROBIN K · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR001449NICHD NIH HHS R01 HD059856NIGMS NIH HHS P20 GM109089NIH NICHD R01-HD059856University of New Mexico Clinical and Translational Science Center UL1 TR001449
6 · The paper itself

Abstract

backgroundErythropoiesis stimulating agents (ESAs) are neuroprotective in cell and animal models of preterm birth. Prematurity has been shown to alter neurometabolite levels in children in studies using proton magnetic resonance spectroscopy (1H-MRS).

objectiveWe hypothesized that ESA treatment in premature infants would tend to normalize neurometabolites by 4-6 years of age. MATERIALS AND

methodsChildren in a longitudinal study of neurodevelopment underwent MRI and 1H-MRS at approximately 4 years and 6 years of age. Prematurely born children (500-1,250 g birth weight) received ESAs (erythropoietin or darbepoetin) or placebo during their neonatal hospitalization, and these groups were compared to healthy term controls. 1H-MRS spectra were obtained from the anterior cingulate (gray matter) and frontal lobe white matter, assessing combined N-acetylaspartate and N-acetylaspartylglutamate (tNAA), myo-inositol, choline compounds (Cho), combined creatine and phosphocreatine, and combined glutamate and glutamine.

resultsNo significant (P≤0.5) group differences were observed for any metabolite level. Significant age-related increases in white-matter tNAA and Cho were observed, as well as a trend for increased gray-matter tNAA.

conclusionNeither prematurity nor neonatal ESA treatment was associated with differences in brain metabolite levels in the children of this study at a significance level of 0.05. These findings suggest that earlier differences that might have existed had normalized by 4-6 years of age or were too small to be statistically significant in the current sample.

Indexed as

Infant, PrematureBiomarkersBrainChildChild, PreschoolFemaleHematinicsHumansInfant, NewbornLongitudinal StudiesMagnetic Resonance ImagingMaleProton Magnetic Resonance SpectroscopySignal-To-Noise RatioBiomarkersHematinicsBrainChildrenErythropoiesis stimulating agentsPrematurityProton magnetic resonance spectroscopy

Identifiers

PMID29335880
PMCPMC5823776
OpenAlexW2782654436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.