ArticleJournal of bone and mineral metabolism2019
Association between frailty and bone loss in patients undergoing maintenance hemodialysis.
Article in Journal of bone and mineral metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- The prevalence of frailty among older adults with maintenance hemodialysis: a systematic.BMC nephrology · 2025Pooled it
- Global prevalence of frailty in hemodialysis patients: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association between frailty and adverse outcomes in patients undergoing maintenance hemodialysis: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- The prevalence of frailty in patients on hemodialysis: a systematic review and meta-analysis.International urology and nephrology · 2020Pooled it
- The impact of frailty on the survival prognosis of maintenance hemodialysis patients and the construction and validation of a survival prediction model.International urology and nephrology · 2026Article
- Development of a Lasso-Nomogram-Based Risk Prediction Model for Cognitive Frailty in Elderly MHD Patients.Neuropsychiatric disease and treatment · 2025Article
- Beyond sarcopenia: frailty in chronic haemodialysis patients.Clinical kidney journal · 2024Article
- A machine learning-based assistant tool for early frailty screening of patients receiving maintenance hemodialysis.International urology and nephrology · 2024Article
- The implication of calf circumference and grip strength in osteoporosis and bone mineral density among hemodialysis patients.Clinical and experimental nephrology · 2023Article
- Emerging cross-talks between chronic kidney disease-mineral and bone disorder (CKD-MBD) and malnutrition-inflammation complex syndrome (MICS) in patients receiving dialysis.Clinical and experimental nephrology · 2022Review
- Study on the Clinical Implications of NLR and PLR for Diagnosing Frailty in Maintenance Hemodialysis Patients and Their Correlations with Patient Prognosis.Journal of healthcare engineering · 2022Article
- Design and methodology of the Aging Nephropathy Study (AGNES): a prospective cohort study of elderly patients with chronic kidney disease.BMC nephrology · 2020Article
- Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Chronic kidney disease-related osteoporosis is associated with incident frailty among patients with diabetic kidney disease: a propensity score-matched cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- Article
- Contributors, risk associates, and complications of frailty in patients with chronic kidney disease: a scoping review.Therapeutic advances in chronic disease · 2019Article
- Does Dietary Intake Differ in Kidney Failure Patients With Sarcopenia and Frailty Treated by Hemodialysis.Gerontology & geriatric medicineArticle
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Frailty is significantly associated with bone loss in the general population. However, it is unclear whether this association also exists in patients undergoing hemodialysis who have chronic kidney disease-mineral and bone disorder (CKD-MBD). This study aimed to assess the association between frailty and bone loss in patients undergoing hemodialysis. This cross-sectional study included 214 (90 women, 124 men) Japanese outpatients undergoing maintenance hemodialysis three times per week, with a mean age of 67.1 years (women) and 66.8 years (men). Frailty was defined based on criteria set forth by the Cardiovascular Health Study (CHS)-19 (21.1%) women and 47 (37.9%) men were robust, 41 (45.6%) women and 43 (34.7%) men were pre-frail, and 30 (33.3%) women and 34 (27.4%) men were frail. For bone mass, quantitative ultrasound (QUS) parameters (speed of sound, broadband ultrasound attenuation, stiffness index) of the calcaneus were measured. The association between frailty and QUS parameters was determined separately for women and men using multivariate analysis of covariance (ANCOVA), with adjustments for clinical characteristics including age, body mass index, hemodialysis vintage, diabetes, current smoking, serum albumin, phosphate, corrected calcium, intact parathyroid hormone, and medication for CKD-MBD (vitamin D receptor activator, calcimimetics). ANCOVA revealed that all QUS parameters declined significantly with increasing levels of frailty in both sexes (P < 0.05). In conclusion, frailty (as defined by CHS criteria) should be considered a risk factor for bone loss in patients undergoing hemodialysis.
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