Evidence map›Paper›PMID 29335764›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2018

Pulmonary

Thida Win, Nicholas J Screaton, Joanna C Porter, Balaji Ganeshan, Toby M Maher, Francesco Fraioli, Raymondo Endozo, Robert I Shortman, Lynn Hurrell, Beverley F Holman and 7 more

Open access · hybridAbstract readClinical Trial
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 82 citations in OpenAlex.

  1. Chemokine Receptor 2-targeted Molecular Imaging in Pulmonary Fibrosis. A Clinical Trial.American journal of respiratory and critical care medicine · 2021
    Trial
  2. Pulmonary [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Assessment of the Diagnostic Value of [Diagnostics (Basel, Switzerland) · 2025
    Article
  5. EJNMMI research · 2025
    Article
  6. Initial [European journal of nuclear medicine and molecular imaging · 2025
    Article
  7. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  8. Molecular Imaging of Pulmonary Fibrosis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  9. Prognostic value of [Scientific reports · 2025
    Article
  10. Frontiers in medicine · 2025
    Article
  11. Article
  12. Review
  13. [Pharmaceuticals (Basel, Switzerland) · 2024
    Article
  14. Article
  15. [Science advances · 2024
    Article
  16. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  17. Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Thida WinRespiratory Medicine, Lister Hospital, Stevenage, UK.
Nicholas J ScreatonRadiology Department, Papworth Hospital, Papworth Everard, Cambridge, UK.
Joanna C PorterCITR, UCL and Interstitial Lung Disease Centre, UCLH, London, UK.
Balaji GaneshanInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Toby M MaherInterstitial Lung Disease Unit, Royal Brompton Hospital, London, UK.
Francesco FraioliInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Raymondo EndozoInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Robert I ShortmanInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Lynn HurrellInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Beverley F HolmanInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Kris ThielemansInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Alaleh RashidnasabInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Brian F HuttonInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Pauline T LukeyFibrosis and Lung Injury DPU, GlaxoSmithKline R&D, Stevenage, UK.
Aiden FlynnStatistical Consultancy, Exploristics, Belfast, UK.
Peter J EllInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK.
Ashley M GrovesInstitute of Nuclear Medicine, University College London/Hospital, 5th Floor, 235 Euston Road, London, NW1 2BU, UK. ashleygroves@nhs.net.
University College Hospital · GBUniversity College London · GBExploristics (United Kingdom) · GBGlaxoSmithKline (United Kingdom) · GBLister Hospital · GBPapworth Hospital · GBRoyal Brompton Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThere is a lack of prognostic biomarkers in idiopathic pulmonary fibrosis (IPF) patients. The objective of this study is to investigate the potential of

methodsA total of 113 IPF patients (93 males, 20 females, mean age ± SD: 70 ± 9 years) were prospectively recruited for

resultsDuring a mean follow-up of 29 months, there were 54 deaths. The mean TBR ± SD was 5.6 ± 2.7. Mortality was associated with high pulmonary TBR (p = 0.009), low forced vital capacity (FVC; p = 0.001), low transfer factor (TLCO; p < 0.001), high GAP index (p = 0.003), and high GAP stage (p = 0.003). Stepwise forward-Wald-Cox analysis revealed that the pulmonary TBR was independent of GAP classification (p = 0.010). The median survival in IPF patients with a TBR < 4.9 was 71 months, whilst in those with TBR > 4.9 was 24 months. Combining PET data with GAP data ("PET modified GAP score") refined the ability to predict mortality.

conclusionsA high pulmonary TBR is independently associated with increased risk of mortality in IPF patients.

Indexed as

Positron Emission Tomography Computed TomographyAgedFemaleFluorodeoxyglucose F18HumansIdiopathic Pulmonary FibrosisLungMaleMiddle AgedPositron-Emission TomographyRisk AssessmentTomography, X-Ray ComputedFluorodeoxyglucose F18Fluorine-18 FDGInterstitial lung diseasePositron-emission tomography and computed tomography

Identifiers

PMID29335764
PMCPMC5978900
OpenAlexW2782843494

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.