Evidence map›Paper›PMID 29335751›Full record

Trial reportExperimental brain research2018

Transcranial direct current stimulation enhances foot sole somatosensation when standing in older adults.

Junhong Zhou, On-Yee Lo, Lewis A Lipsitz, Jue Zhang, Jing Fang, Brad Manor

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Junhong ZhouHebrew SeniorLife Institute for Aging Research, Harvard Medical School, Roslindale, MA, USA. junhongzhou@hsl.harvard.edu.ORCID 0000-0002-7931-7646
On-Yee LoHebrew SeniorLife Institute for Aging Research, Harvard Medical School, Roslindale, MA, USA.
Lewis A LipsitzHebrew SeniorLife Institute for Aging Research, Harvard Medical School, Roslindale, MA, USA.
Jue ZhangAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. zhangjue@pku.edu.cn.
Jing FangAcademy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Brad ManorHebrew SeniorLife Institute for Aging Research, Harvard Medical School, Roslindale, MA, USA.
Beth Israel Deaconess Medical Center · USPeking University · CN

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Translational Researchin Aging Trainnig ProgramT32AG023480 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2004 to 2024
$7.6M
Health Outcomes of Tai Chi in Subsidized Senior HousingR01AG025037 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS, WAYNE, PETER MICHAEL · 2015 to 2019
$3.5M
Cerebrovascular Mechanisms of Slow Gait and FallsR01AG041785 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2013 to 2017
$2.4M
Nonlinear Dynamics of Frailty in AgingR37AG025037 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI LIPSITZ, LEWIS · 2006 to 2013
$1.6M
Modulating brain activity to preserve gait in older adults.K01AG044543 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MANOR, BRADLEY D. · 2014 to 2016
$373k
National Natural Science Foundation of China 11372013National Natural Science Foundation of China 11572003NCATS NIH HHS UL1 TR001102NIA NIH HHS 1-K01-AG044543-01A1NIA NIH HHS AG025037NIA NIH HHS AG041785NIA NIH HHS K01 AG044543NIA NIH HHS R01 AG025037NIA NIH HHS R01 AG041785NIA NIH HHS R37 AG025037NIA NIH HHS T32 AG023480
6 · The paper itself

Abstract

Foot-sole somatosensation is critical for safe mobility in older adults. Somatosensation arises when afferent input activates a neural network that includes the primary somatosensory cortex. Transcranial direct current stimulation (tDCS), as a strategy to increase somatosensory cortical excitability, may, therefore, enhance foot-sole somatosensation. We hypothesized that a single session of tDCS would improve foot-sole somatosensation, and thus mobility, in older adults. Twenty healthy older adults completed this randomized, double-blinded, cross-over study consisting of two visits separated by one week. On each visit, standing vibratory threshold (SVT) of each foot and the timed-up-and-go test (TUG) of mobility were assessed immediately before and after a 20-min session of tDCS (2.0 mA) or sham stimulation with the anode placed over C3 (according to the 10/20 EEG placement system) and the cathode over the contralateral supraorbital margin. tDCS condition order was randomized. SVT was measured with a shoe insole system. This system automatically ramped up, or down, the amplitude of applied vibrations and the participant stated when they could or could no longer feel the vibration, such that lower SVT reflected better somatosensation. The SVTs of both foot soles were lower following tDCS as compared to sham and both pre-test conditions [F

Indexed as

AgedCross-Over StudiesDouble-Blind MethodFootHumansMiddle AgedPostureSensory ThresholdsSomatosensory CortexTouch PerceptionTranscranial Direct Current StimulationVibrationFoot sole somatosensationMobilityStanding vibratory thresholdtDCSTimed-up and go test

Identifiers

PMID29335751
PMCPMC5828881
OpenAlexW2783005654

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.