ArticleNature neuroscience2018
Grid scale drives the scale and long-term stability of place maps.
Article in Nature neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.Nature communications · 2025Article
- Article
- Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.eLife · 2025Article
- Robust variability of grid cell properties within individual grid modules enhances encoding of local space.bioRxiv : the preprint server for biology · 2024Article
- Space is a latent sequence: A theory of the hippocampus.Science advances · 2024Article
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ketamine evoked disruption of entorhinal and hippocampal spatial maps.Nature communications · 2023Article
- Multiple memory systems for efficient temporal order memory.Hippocampus · 2023Article
- T-type CaCell reports · 2023Article
- Ketamine evoked disruption of entorhinal and hippocampal spatial maps.bioRxiv : the preprint server for biology · 2023Article
- The grid code for ordered experience.Nature reviews. Neuroscience · 2021Review
- Dynamic and reversible remapping of network representations in an unchanging environment.Neuron · 2021Article
- Flexible modulation of sequence generation in the entorhinal-hippocampal system.Nature neuroscience · 2021Article
- Perineuronal nets stabilize the grid cell network.Nature communications · 2021Article
- Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories.Nature reviews. Neuroscience · 2020Review
- Article
- Entorhinal velocity signals reflect environmental geometry.Nature neuroscience · 2020Article
- The neural circuitry supporting successful spatial navigation despite variable movement speeds.Neuroscience and biobehavioral reviews · 2020Review
- A Brain-Inspired Adaptive Space Representation Model Based on Grid Cells and Place Cells.Computational intelligence and neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Medial entorhinal cortex (MEC) grid cells fire at regular spatial intervals and project to the hippocampus, where place cells are active in spatially restricted locations. One feature of the grid population is the increase in grid spatial scale along the dorsal-ventral MEC axis. However, the difficulty in perturbing grid scale without impacting the properties of other functionally defined MEC cell types has obscured how grid scale influences hippocampal coding and spatial memory. Here we use a targeted viral approach to knock out HCN1 channels selectively in MEC, causing the grid scale to expand while leaving other MEC spatial and velocity signals intact. Grid scale expansion resulted in place scale expansion in fields located far from environmental boundaries, reduced long-term place field stability and impaired spatial learning. These observations, combined with simulations of a grid-to-place cell model and position decoding of place cells, illuminate how grid scale impacts place coding and spatial memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.