ArticleScientific reports2018
An evaluation of the effect of pulse-shape on grey and white matter stimulation in the rat brain.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electrical stimulation of the nucleus basalis of meynert: a systematic review of preclinical and clinical data.Scientific reports · 2021Pooled it
- Temporal interference stimulation of peripheral nerves induces functionally diverse limb movements revealed by automated pose estimation and unsupervised behavioral analysis.Journal of neuroengineering and rehabilitation · 2025Article
- An arbitrary waveform neurostimulator for preclinical studies: design and verification.Medical & biological engineering & computing · 2025Article
- Optimal interphase delay in biphasic current pulses facilitates neural circuit activation induced by microstimulation in the mouse visual cortex.Frontiers in neuroscience · 2025Article
- Microstimulation-based path tracking control of pigeon robots through parameter adaptive strategy.Heliyon · 2024Article
- Imaging the stability of chronic electrical microstimulation using electrodes coated with PEDOT/CNT and iridium oxide.iScience · 2022Article
- Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model.PLoS computational biology · 2021Article
- Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain.Frontiers in aging neuroscience · 2021Article
- tACS motor system effects can be caused by transcutaneous stimulation of peripheral nerves.Nature communications · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the current success of neuromodulation, standard biphasic, rectangular pulse shapes may not be optimal to achieve symptom alleviation. Here, we compared stimulation efficiency (in terms of charge) between complex and standard pulses in two areas of the rat brain. In motor cortex, Gaussian and interphase gap stimulation (IPG) increased stimulation efficiency in terms of charge per phase compared with a standard pulse. Moreover, IPG stimulation of the deep mesencephalic reticular formation in freely moving rats was more efficient compared to a standard pulse. We therefore conclude that complex pulses are superior to standard stimulation, as less charge is required to achieve the same behavioral effects in a motor paradigm. These results have important implications for the understanding of electrical stimulation of the nervous system and open new perspectives for the design of the next generation of safe and efficient neural implants.
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Registered trials
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