Evidence map›Paper›PMID 29335509›Full record

ArticleScientific reports2018

Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells.

Anping Song, Ling Zhu, Gowthami Gorantla, Olimpia Berdysz, Stephanie A Amici, Mireia Guerau-de-Arellano, Kathryn M Madalena, Jessica K Lerch, Xiaoyu Liu, Ning Quan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 47 citations in OpenAlex.

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  13. Decoding IL-1 receptor 1 and 2 expression profiles across organs in sepsis.Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Anping SongDepartment of Oncolgy, Tongji Hospital, Huazhong University of Science and Technology Tongji Medical College, Wuhan, Hubei, 430030, P. R. China.
Ling ZhuInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Gowthami GorantlaInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Olimpia BerdyszInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Stephanie A AmiciInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Mireia Guerau-de-ArellanoInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Kathryn M MadalenaDepartment of Neuroscience, The Ohio State University, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0002-3477-5993
Jessica K LerchDepartment of Neuroscience, The Ohio State University, Columbus, OH, 43210, USA.
Xiaoyu LiuInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA. liu.1933@osu.edu.
Ning QuanInstitute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA. quan.14@osu.edu.
Institute for Behavioral Medicine · USThe Ohio State University · USThe Ohio State University Wexner Medical Center · USTongji Hospital · CNWest China Medical Center of Sichuan University · CN

Funding

Epigenetic modulation of T cell tolerance in Multiple Sclerosis autoimmunityR01AI121405 · NIAID · OHIO STATE UNIVERSITY · PI GUERAU-DE-ARELLANO, MIREIA · 2016 to 2020
$2.2M
Anxiety, IL-1R1 and neuroinflammationR01MH109165 · NIMH · OHIO STATE UNIVERSITY · PI QUAN, NING · 2016 to 2020
$1.9M
Novel Epigenetic Modifier Inhibitor Drugs for T cell Modulation in Multiple SclerosisR21AI127354 · NIAID · OHIO STATE UNIVERSITY · PI GUERAU-DE-ARELLANO, MIREIA · 2017 to 2018
$404k
NIAID NIH HHS R01 AI121405NIAID NIH HHS R21 AI127354NIMH NIH HHS R01 MH109165
6 · The paper itself

Abstract

Interleukin 1 is a pleiotropic cytokine that mediates diverse functions through its receptor, type I interleukin 1 receptor (IL-1R1). Most previous studies have focused on the expression and function of IL-1R1 in immune cells. Here we performed a comprehensive mapping of IL-1R1 distribution in multiple peripheral tissues using our IL-1R1 reporter (IL-1R1

Indexed as

Gene Expression ProfilingAnimalsAnimal StructuresMiceReceptors, Interleukin-1Receptors, Interleukin-1

Identifiers

PMID29335509
PMCPMC5768710
OpenAlexW2782950198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.