ArticleScientific reports2018
Bioimpedimetric analysis in conjunction with growth dynamics to differentiate aggressiveness of cancer cells.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 45 citations in OpenAlex.
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- Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion.Cell death & disease · 2023Article
- Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells.Journal of cell communication and signaling · 2023Article
- Bio-inspired microfluidics: A review.Biomicrofluidics · 2023Review
- Learning models for classifying Raman spectra of genomic DNA from tumor subtypes.Scientific reports · 2023Article
- Senescent Secretome of Blind Mole RatInternational journal of molecular sciences · 2023Article
- PARP targeted Auger emitter therapy with [EJNMMI research · 2022Article
- A Novel Microwave Resonant Sensor for Measuring Cancer Cell Line Aggressiveness.Sensors (Basel, Switzerland) · 2022Article
- Toward Multitasking Pharmacological COX-Targeting Agents: Non-Steroidal Anti-Inflammatory Prodrugs with Antiproliferative Effects.Molecules (Basel, Switzerland) · 2021Article
- The Measurement and Analysis of Impedance Response of HeLa Cells to Distinct Chemotherapy Drugs.Micromachines · 2021Article
- Tactile sensing biohybrid soft E-skin based on bioimpedance using aloe vera pulp tissues.Scientific reports · 2021Article
- Bidirectional Tumor-Promoting Activities of Macrophage Ezrin.International journal of molecular sciences · 2020Article
- Use of Discrete Wavelet Transform to Assess Impedance Fluctuations Obtained from Cellular Micromotion.Sensors (Basel, Switzerland) · 2020Article
- Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells.Biology · 2020Article
- Development and verification of a three-dimensional (3D) breast cancer tumor model composed of circulating tumor cell (CTC) subsets.Molecular biology reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determination of cancer aggressiveness is mainly assessed in tissues by looking at the grade of cancer. There is a lack of specific method to determine aggressiveness of cancer cells in vitro. In our present work, we have proposed a bio-impedance based non-invasive method to differentiate aggressive property of two breast cancer cell lines. Real-time impedance analysis of MCF-7 (less aggressive) and MDA-MB-231 cells (more aggressive) demonstrated unique growth pattern. Detailed slope-analysis of impedance curves at different growth phases showed that MDA-MB-231 had higher proliferation rate and intrinsic resistance to cell death, when allowed to grow in nutrient and space limiting conditions. This intrinsic nature of death resistance of MDA-MB-231 was due to modulation and elongation of filopodia, which was also observed during scanning electron microscopy. Results were also similar when validated by cell cycle analysis. Additionally, wavelet based analysis was used to demonstrate that MCF-7 had lesser micromotion based cellular activity, when compared with MDA-MB-231. Combined together, we hypothesize that analysis of growth rate, death resistance and cellular energy, through bioimpedance based analysis can be used to determine and compare aggressiveness of multiple cancer cell lines. This further opens avenues for extrapolation of present work to human tumor tissue samples.
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