ArticleScientific reports2018
LPS-induced Vitamin D Receptor Decrease in Oral Keratinocytes Is Associated With Oral Lichen Planus.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Role of Vitamin D and Vitamin D Receptor in Oral Lichen Planus: A Systematic Review.Ethiopian journal of health sciences · 2020Pooled it
- The role of vitamin D in amelioration of oral lichen planus and its effect on salivary and tissue IFN-γ level: a randomized clinical trial.BMC oral health · 2024Trial
- Bioactive Polysaccharides from FermentedMolecules (Basel, Switzerland) · 2025Article
- RNA modifications at the heart of oral inflammation.Molecular therapy. Nucleic acids · 2025Article
- Role of E-cadherin in epithelial barrier dysfunction: implications for bacterial infection, inflammation, and disease pathogenesis.Frontiers in cellular and infection microbiology · 2025Review
- Role of micronutrition in patients with oral cancer and nutritional intervention strategies.Frontiers in nutrition · 2025Review
- Fraxin alleviates oral lichen planus by suppressing OCT3-mediated activation of FGF2/NF-κB pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Evaluation of the Function of Vitamin D in Treating Oral Lichen Planus.Journal of pharmacy & bioallied sciences · 2024Article
- Autophagy as a potential mechanism underlying the biological effect of 1,25-Dihydroxyvitamin D3 on periodontitis: a narrative review.BMC oral health · 2023Review
- 25-Hydroxyvitamin D potentializes extracellular cathelicidin release from human PBMC stimulated ex vivo with either bacterial (LPS) or viral (P: IC) mimetics.Journal of physiology and biochemistry · 2022Article
- Anti-Inflammatory Effect of Liverwort (Plants (Basel, Switzerland) · 2021Article
- Helicobacter pylori infection is correlated with the incidence of erosive oral lichen planus and the alteration of the oral microbiome composition.BMC microbiology · 2021Article
- MicroRNA-122 promotes apoptosis of keratinocytes in oral lichen planus through suppressing VDR expression.Journal of cellular and molecular medicine · 2021Article
- Micronutrients Profile in Oral Lichen Planus: a Review Literature.Biological trace element research · 2021Review
- Renin Promotes STAT4 Phosphorylation to Induce IL-17 Production in Keratinocytes of Oral Lichen Planus.iScience · 2020Article
- Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population.BMC oral health · 2020Article
- Vitamin D/VDR signaling induces miR-27a/b expression in oral lichen planus.Scientific reports · 2020Article
- Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α.Journal of periodontal & implant science · 2019Article
- The Protective Role of Feruloylserotonin in LPS-Induced HaCaT Cells.Molecules (Basel, Switzerland) · 2019Article
- Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway.Cell communication and signaling : CCS · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The suppressive function of vitamin D on oral lichen planus (OLP) have been documented previously. Vitamin D receptor (VDR) expression is down-regulated in OLP, but the molecular mechanism of its decrease and the related anti-inflammatory contributor of epithelial VDR signaling is unclear. Herein, we demonstrated that lipopolysaccharide (LPS) remarkedly down-regulated VDR expression of keratinocytes, and the reduced regulation was dependent on tumor necrosis factor alpha (TNFα)-miR-346 pathway. In human specimen studies, VDR levels of oral mucosal epithelia from OLP patients decreased substantially accompanied with robust TNFα and miR-346 induction, compared to the normal tissues. In addition, vitamin D/VDR signaling inhibited LPS-induced p53-upregulated modulator of apoptosis (PUMA) induction in keratinocytes via impeding nuclear factor-κB (NF-κB) activation, resulting in keratinocytes apoptosis reduction. Importantly, PUMA activity was up-regulated strongly in diseased epithelium, reversely correlated with VDR expression. Totally, our data indicate that LPS is responsible for VDR downregulation in oral keratinocytes, which is associated with OLP development.
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