ArticleSpinal cord2018
Low vitamin D levels are independent predictors of 1-year worsening in physical function in people with chronic spinal cord injury: a longitudinal study.
Article in Spinal cord, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Impact of vitamin D on the prognosis after spinal cord injury: A systematic review.Frontiers in nutrition · 2023Pooled it
- Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis.Endocrine · 2021Pooled it
- The effects of weekly or daily oral cholecalciferol use on muscle strength, muscle thickness, and functional independence in patients with spinal cord injury.Turkish journal of physical medicine and rehabilitation · 2025Article
- Independent association of hypovitaminosis d with non-alcoholic fatty liver disease in people with chronic spinal cord injury: a cross-sectional study.Journal of endocrinological investigation · 2024Article
- Vitamin D Supplementation in Functional Recovery of Subjects with Severe Acquired Brain Injury: A Pilot Controlled Randomized Study.Neurotrauma reports · 2024Article
- 25-Hydroxyvitamin D Levels and Vitamin D3 Supplementation During Postacute Spinal Cord Injury Rehabilitation.Topics in spinal cord injury rehabilitation · 2024Observational
- The Pathophysiology, Identification and Management of Fracture Risk, Sublesional Osteoporosis and Fracture among Adults with Spinal Cord Injury.Journal of personalized medicine · 2023Review
- Vitamin D Promotes Remyelination by Suppressing c-Myc and Inducing Oligodendrocyte Precursor Cell Differentiation after Traumatic Spinal Cord Injury.International journal of biological sciences · 2022Article
- miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury.Experimental biology and medicine (Maywood, N.J.) · 2021Article
- Testosterone, level of the lesion and age are independently associated with prostate volume in men with chronic spinal cord injury.Journal of endocrinological investigation · 2020Article
- Comment on: Plasma vitamin D, past chest illness, and risk of future chest illness in chronic spinal cord injury (SCI): a longitudinal observational study.Spinal cord · 2020Article
- B Cell-Activating Factor Is Associated with Testosterone and Smoking Status in Non-Ambulatory Men with Chronic Spinal Cord Injury.Journal of neurotrauma · 2019Article
- Can the positive association of osteocalcin with testosterone be unmasked when the preeminent hypothalamic-pituitary regulation of testosterone production is impaired? The model of spinal cord injury.Journal of endocrinological investigation · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designLongitudinal cohort study.
objectiveTo explore the longitudinal association of baseline vitamin D levels with 1-year change in physical function outcomes in people with chronic spinal cord injury (SCI).
settingRehabilitation institute.
methodsSixty-seven patients (44 men and 23 women) with chronic SCI admitted to a rehabilitation program were included. Functional independence in daily living activities (as evaluated by the Spinal Cord Independence Measure version III, SCIM III) and leisure time physical activity (LTPA) were assessed as measures of physical function at the admission and re-assessed 1-year later. Comorbidity was scored by Charlson comorbidity index (CCI).
resultsA 1-year worsening in SCIM and LTPA were registered in 44 and 40 patients (66% and 60% of the study population), respectively. They exhibited significantly lower baseline 25(OH)D levels, higher CCI, and shorter distance from the injury. At the multiple linear regression analyses, lower baseline 25(OH)D levels exhibited a significant independent association with higher percentages of 1-year worsening in both SCIM and LTPA. At ROC analysis, baseline 25(OH)D levels <18.6 and <18.2 ng/mL discriminated individuals with 1-year worsening in SCIM and LTPA, respectively. According to these cut-off points, at the multiple logistic regression analysis, patients with low baseline 25(OH)D levels exhibited an OR of worsening in SCIM and LTPA engagement 2.8- and 2.6-fold higher, after adjustment for CCI, distance from injury, and post-follow-up 25(OH)D levels.
conclusionsIn people with chronic SCI, a low 25(OH)D level may represent an independent predictor of worsening in physical function outcomes over time.
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Registered trials
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