ArticleScientific reports2018
The high concentration of progesterone is harmful for endometrial receptivity and decidualization.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- The efficacy of acupuncture on endometrial receptivity in infertile women: an overview of systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Novel insights on premature progesterone elevation: a mini-review.JBRA assisted reproduction · 2022Pooled it
- Acupuncture in improving endometrial receptivity: a systematic review and meta-analysis.BMC complementary and alternative medicine · 2019Pooled it
- Differential Expression and Function of Arginase in Mouse Uterus During Early Pregnancy.International journal of molecular sciences · 2026Article
- A retrospective study of the relationship between low-density lipoprotein cholesterol and pregnancy outcomes after assisted reproductive technology treatments in women with diabetes mellitus and infertility.AJOG global reports · 2026Article
- Decidualization-empowered ECM hydrogel integrating sustained Tβ4 release drives endometrial regeneration in intrauterine adhesions.Nature communications · 2026Article
- [Research progress on the roles of primary cilia in fertility].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Review
- Incidence and risk factors of monozygotic twinning following ART: analysis of 154 671 live births resulting from single embryo transfer.Human reproduction (Oxford, England) · 2025Article
- Review
- Effect of progesterone levels on the hCG trigger day and the progesterone-to-basal progesterone ratio on pregnancy outcomes in fresh IVF/ICSI cycles with GnRH antagonist protocol: a retrospective cohort study.Frontiers in endocrinology · 2025Article
- Excessive progesterone impairs mouse decidualization via the Kyn-AhR pathway.Frontiers in cell and developmental biology · 2025Article
- Metformin in polycystic ovary syndrome: unraveling multi-stage therapeutic mechanisms from puberty to long-term health outcomes.Frontiers in pharmacology · 2025Review
- Acupuncture as an adjunct therapy for enhancing endometrial receptivity in female infertility: a literature review.Frontiers in physiology · 2025Review
- Uterine cyclin A2-deficient mice as a model of female early pregnancy loss.The Journal of clinical investigation · 2024Article
- High serum progesterone levels on the day of embryo transfer in patients undergoing artificial frozen-thawed blastocyst transfer: Is there a ceiling effect?Turkish journal of obstetrics and gynecology · 2024Article
- In vitro fertilization results of GNRH antagonists and medroxyprogesterone acetate used to prevent premature LH surge during ovarian hyperstimulation.Scientific reports · 2024Article
- Review
- Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress.Acta biochimica et biophysica Sinica · 2024Article
- Investigating the role of oviductal mucosa-endometrial co-culture in modulating factors relevant to embryo implantation.Open medicine (Warsaw, Poland) · 2024Article
- Activation of SGK1/ENaC Signaling Pathway Improves the Level of Decidualization in Unexplained Recurrent Spontaneous Abortion.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization. Our data indicate that excess progesterone is not only harmful for mouse implantation, but also impairs mouse decidualization. In excess progesterone-treated mice, the impaired LIF/STAT3 pathway and dysregulated endoplasmic reticulum stress may lead to the inhibition of embryo implantation and decidualization. It is possible that the decrease in birth weight of excess progesterone-treated mice is due to a compromised embryo implantation and decidualization. Furthermore, excess progesterone compromises in vitro decidualization of human endometrial stromal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.