Evidence map›Paper›PMID 29335448›Full record

ArticleScientific reports2018

Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese.

Kevin Y Urayama, Masatoshi Takagi, Takahisa Kawaguchi, Keitaro Matsuo, Yoichi Tanaka, Yoko Ayukawa, Yuki Arakawa, Daisuke Hasegawa, Yuki Yuza, Takashi Kaneko and 25 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 20 institutions in 1 country.

Kevin Y UrayamaDepartment of Social Medicine, National Center for Child Health and Development, Tokyo, Japan. urayama-k@ncchd.go.jp.
Masatoshi TakagiDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-7580-9184
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Keitaro MatsuoDivision of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Aichi, Japan.ORCID http://orcid.org/0000-0003-1761-6314
Yoichi TanakaDepartment of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan.
Yoko AyukawaDepartment of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
Yuki ArakawaDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Daisuke HasegawaDepartment of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.
Yuki YuzaDepartment of Hematology/Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Takashi KanekoDepartment of Hematology/Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Yasushi NoguchiDepartment of Pediatrics, Japanese Red Cross Narita Hospital, Chiba, Japan.
Yuichi TaneyamaDepartment of Hematology/Oncology, Chiba Children's Hospital, Chiba, Japan.
Setsuo OtaDepartment of Pediatrics, Teikyo University Chiba Medical Center, Chiba, Japan.
Takeshi InukaiDepartment of Pediatrics, University of Yamanashi, Yamanashi, Japan.
Masakatsu YanagimachiDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
Dai KeinoDepartment of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.
Kazutoshi KoikeDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan.
Daisuke ToyamaDivision of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan.
Yozo NakazawaDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.ORCID http://orcid.org/0000-0003-0793-815X
Hidemitsu KurosawaDepartment of Pediatrics, Dokkyo Medical University, Tochigi, Japan.
Kozue NakamuraDepartment of Pediatrics, Teikyo University Hospital, Tokyo, Japan.
Koichi MoriwakiDepartment of Pediatrics, Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Hiroaki GotoDivision of Hematology/Oncology & Regenerative Medicine, Kanagawa Children's Medical Center, Yokohama, Japan.
Yujin SekinakaDepartment of Pediatrics, National Defense Medical College, Saitama, Japan.
Daisuke MoritaDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
Motohiro KatoChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Junko TakitaDepartment of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan.
Toshihiro TanakaDepartment of Human Genetics and Disease Diversity, Tokyo Medical Dental University, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6201-9784
Johji InazawaBioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan.
Katsuyoshi KohDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Yasushi IshidaPediatric Medical Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
Akira OharaDepartment of Pediatrics, Toho University, Tokyo, Japan.
Shuki MizutaniDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Atsushi ManabeDepartment of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6698-2348
Tokyo Medical and Dental University · JPKyoto University · JPNational Center For Child Health and Development · JPSaitama Children's Medical Center · JPShinshu University · JPSt. Luke's International Hospital · JPTokyo Metropolitan Children's Medical Center · JPAichi Cancer Center · JPChiba Hospital · JPDokkyo Medical University · JPEhime Prefectural Central Hospital · JPIbaraki Children's Hospital · JPJapanese Red Cross Narita Hospital · JPKanagawa Children's Medical Center · JPKitasato University · JPNational Defense Medical College · JPShowa University Fujigaoka Hospital · JPSocial Insurance Saitama Chuo Hospital · JPSt. Luke's International University · JPSt. Marianna University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome-wide association studies (GWAS) performed mostly in populations of European and Hispanic ancestry have confirmed an inherited genetic basis for childhood acute lymphoblastic leukemia (ALL), but these associations are less clear in other races/ethnicities. DNA samples from ALL patients (aged 0-19 years) previously enrolled onto a Tokyo Children's Cancer Study Group trial were collected during 2013-2015, and underwent single nucleotide polymorphism (SNP) microarray genotyping resulting in 527 B-cell ALL for analysis. Cases and control data for 3,882 samples from the Nagahama Study Group and Aichi Cancer Center Study were combined, and association analyses across 10 previous GWAS-identified regions were performed after targeted SNP imputation. Linkage disequilibrium (LD) patterns in Japanese and other populations were evaluated using the varLD score based on 1000 Genomes data. Risk associations for ARID5B (rs10821936, OR = 1.84, P = 6 × 10

Indexed as

Genetic Predisposition to DiseaseAdolescentAsian PeopleChildChild, PreschoolDNA-Binding ProteinsFemaleGenetic LociGenome-Wide Association StudyHumansIkaros Transcription FactorInfantInfant, NewbornJapanLinkage DisequilibriumMaleARID5B protein, humanDNA-Binding ProteinsIkaros Transcription FactorIKZF1 protein, humanPhosphotransferases (Alcohol Group Acceptor)PIP4K2A protein, humanTranscription Factors

Identifiers

PMID29335448
PMCPMC5768812
OpenAlexW2784248773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.