Evidence map›Paper›PMID 29335441›Full record

ArticleScientific reports2018

A Collective Route to Head and Neck Cancer Metastasis.

Arutha Kulasinghe, Henri Schmidt, Chris Perry, Bernard Whitfield, Liz Kenny, Colleen Nelson, Majid E Warkiani, Chamindie Punyadeera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  6. Patterns of Distant Metastasis in Head and Neck Cancer in a Tertiary Care Centre.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023
    Article
  7. Review
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  10. Article
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  12. Article
  13. Article
  14. Collective metastasis: coordinating the multicellular voyage.Clinical & experimental metastasis · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arutha KulasingheThe School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Henri SchmidtThe School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Chris PerryDepartment of Otolaryngology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Bernard WhitfieldDepartment of Otolaryngology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Liz KennySchool of Medicine, University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Colleen NelsonAustralian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, Queensland University of Technology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
Majid E WarkianiThe School of Biomedical Engineering, University of Technology, Sydney, NSW, Australia.
Chamindie PunyadeeraThe School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD, Australia. chamindie.punyadeera@qut.edu.au.ORCID http://orcid.org/0000-0002-9424-9661

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Distant metastasis (DM) from head and neck cancers (HNC) portends a poor patient prognosis. Despite its important biological role, little is known about the cells which seed these DM. Circulating tumour cells (CTCs) represent a transient cancer cell population, which circulate in HNC patients' peripheral blood and seed at distant sites. Capture and analysis of CTCs offers insights into tumour metastasis and can facilitate treatment strategies. Whilst the data on singular CTCs have shown clinical significance, the role of CTC clusters in metastasis remains limited. In this pilot study, we assessed 60 treatment naïve HNC patients for CTCs with disease ranging from early to advanced stages, for CTC clusters utilizing spiral CTC enrichment technology. Single CTCs were isolated in 18/60-30% (Ranging from Stage I-IV), CTC clusters in 15/60-25% (exclusively Stage IV) with 3/15-20% of CTC clusters also containing leukocytes. The presence of CTC clusters associated with the development of distant metastatic disease(P = 0.0313). This study demonstrates that CTC clusters are found in locally advanced patients, and this may be an important prognostic marker. In vivo and in vitro studies are warranted to determine the role of these CTC clusters, in particular, whether leukocyte involvement in CTC clusters has clinical relevance.

Indexed as

Neoplastic Cells, CirculatingAcademic Medical CentersAdultAgedAustraliaFemaleHead and Neck NeoplasmsHumansMaleMiddle Aged

Identifiers

PMID29335441
PMCPMC5768780

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.