ArticleScientific reports2018
Grey and white matter volumes either in treatment-naïve or hormone-treated transgender women: a voxel-based morphometry study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of the neural correlates of sexual minority stress: towards an intersectional minority mosaic framework with implications for a future research agenda.European journal of psychotraumatology · 2022Pooled it
- Beyond the Gender Binarism: Neural Correlates of Trans Men in a Functional Connectivity-Resting-State fMRI Pilot Study.Journal of clinical medicine · 2024Article
- Androgyny and atypical sensory sensitivity associated with savant ability: a comparison between Klinefelter syndrome and sexual minorities assigned male at birth.Frontiers in child and adolescent psychiatry · 2024Article
- Accurate sex prediction of cisgender and transgender individuals without brain size bias.Scientific reports · 2023Article
- Endogenous and Exogenous Estrogen Exposures: How Women's Reproductive Health Can Drive Brain Aging and Inform Alzheimer's Prevention.Frontiers in aging neuroscience · 2022Review
- Replication of Previous Findings? Comparing Gray Matter Volumes in Transgender Individuals with Gender Incongruence and Cisgender Individuals.Journal of clinical medicine · 2021Article
- The influence of microsatellite polymorphisms in sex steroid receptor genes ESR1, ESR2 and AR on sex differences in brain structure.NeuroImage · 2020Article
- Biological sex classification with structural MRI data shows increased misclassification in transgender women.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neural Correlates of Gender Face Perception in Transgender People.Journal of clinical medicine · 2020Article
- Sex Matters: A Multivariate Pattern Analysis of Sex- and Gender-Related Neuroanatomical Differences in Cis- and Transgender Individuals Using Structural Magnetic Resonance Imaging.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Cross sex hormone treatment is linked with a reversal of cerebral patterns associated with gender dysphoria to the baseline of cisgender controls.The European journal of neuroscience · 2019Article
- What has sex got to do with it? The role of hormones in the transgender brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- The Evolving Role of Pharmacists in Transgender Health Care.Transgender health · 2019Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many previous magnetic resonance imaging (MRI) studies have documented sex differences in brain morphology, but the patterns of sexual brain differences in transgender women - male sex assigned at birth - with a diagnosis of gender dysphoria (TW) have been rarely investigated to date. We acquired T1-weighted MRI data for the following four (n = 80) groups: treatment-naïve TW (TNTW), TW treated with cross-sex hormones for at least one year (TTW), cisgender men, and cisgender women (cisgender individuals as controls). Differences in whole-brain and regional white matter volume and grey matter volume (GMV) were assessed using voxel-based morphometry. We found lower global brain volumes and regional GMVs in a large portion of the posterior-superior frontal cortex in the cisgender women group than in the TTW and cisgender men groups. Additionally, both transgender groups exhibited lower bilateral insular GMVs than the cisgender women group. Our results highlight differences in the insula in both transgender groups; such differences may be characteristic of TW. Furthermore, these alterations in the insula could be related to the neural network of body perception and reflect the distress that accompanies gender dysphoria.
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