ArticleScientific reports2018
Placental Morphology Is Associated with Maternal Depressive Symptoms during Pregnancy and Toddler Psychiatric Problems.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Maternal Hypertensive Pregnancy Disorders and Mental and Behavioral Disorders in the Offspring: a Review.Current hypertension reports · 2021Pooled it
- Fetal programming of neuropsychiatric disorders by maternal pregnancy depression: a systematic mini review.Pediatric research · 2019Pooled it
- Investigating the association between pain and psychological vulnerabilities and postpartum depression.Scientific reports · 2026Article
- Three-dimensional microarchitecture of the human placental villous tree in health and disease.Frontiers in cell and developmental biology · 2025Review
- Physically active pregnancies: Insights from the placenta.Physiological reports · 2024Review
- Women with psychotic episodes during pregnancy show increased markers of placental damage with Tenney-Parker changes.Histology and histopathology · 2023Article
- The Placentas of Women Who Suffer an Episode of Psychosis during Pregnancy Have Increased Lipid Peroxidation with Evidence of Ferroptosis.Biomolecules · 2023Article
- The association of different presentations of maternal depression with children's socio-emotional development: A systematic review.PLOS global public health · 2023Article
- Couple's Relationship and Depressive Symptoms during the Transition to Parenthood and Toddler's Emotional and Behavioral Problems.International journal of environmental research and public health · 2022Article
- Article
- The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution.Frontiers in cell and developmental biology · 2022Review
- Adverse Pregnancy Outcomes Following the Assassination of John F. Kennedy in 1963.Maternal and child health journal · 2021Article
- A polyepigenetic glucocorticoid exposure score at birth and childhood mental and behavioral disorders.Neurobiology of stress · 2020Article
- The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study.BMC pregnancy and childbirth · 2019Article
- The Density of Cell Nuclei at the Materno-Fetal Exchange Barrier is Sexually Dimorphic in Normal Placentas, but not in IUGR.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
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Abstract
Maternal depressive symptoms during pregnancy predict increased psychiatric problems in children. The underlying biological mechanisms remain unclear. Hence, we examined whether alterations in the morphology of 88 term placentas were associated with maternal depressive symptoms during pregnancy and psychiatric problems in 1.9-3.1-years old (Mean = 2.1 years) toddlers. Maternal depressive symptoms were rated biweekly during pregnancy with the Center of Epidemiological Studies Depression Scale (n = 86). Toddler psychiatric problems were mother-rated with the Child Behavior Checklist (n = 60). We found that higher maternal depressive symptoms throughout pregnancy [B = -0.24 Standard Deviation (SD) units: 95% Confidence Interval (CI) = -0.46; -0.03: P = 0.03; Mean difference = -0.66 SDs; 95% CI = -0.08; -1.23: P = 0.03; between those with and without clinically relevant depressive symptoms] were associated with lower variability in the placental villous barrier thickness of γ-smooth muscle actin-negative villi. This placental morphological change predicted higher total (B = -0.34 SDs: 95% CI = -0.60; -0.07: P = 0.01) and internalizing (B = -0.32 SDs: 95% CI = -0.56; -0.08: P = 0.01) psychiatric problems in toddlers. To conclude, our findings suggest that both maternal depressive symptoms during pregnancy and toddler psychiatric problems may be associated with lower variability in the villous membrane thickness of peripheral villi in term placentas. This lower heterogeneity may compromise materno-fetal exchange, suggesting a possible role for altered placental morphology in the fetal programming of mental disorders.
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