ArticleScientific reports2018
Transspinal Direct Current Stimulation Produces Persistent Plasticity in Human Motor Pathways.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Transspinal direct current stimulation alters neuronal excitability but not homosynaptic inhibition in human spinal cord injury: a pilot clinical trial.Experimental brain research · 2025Trial
- Multisite Hebbian Plasticity Restores Function in Humans with Spinal Cord Injury.Annals of neurology · 2023Trial
- Spinal direct current stimulation (tsDCS) in hereditary spastic paraplegias (HSP): A sham-controlled crossover study.The journal of spinal cord medicine · 2021Trial
- Transcutaneous spinal direct current stimulation shows no effect on paired stimulation suppression of the somatosensory cortex.Scientific reports · 2020Trial
- Article
- Transcutaneous spinal stimulation with upper extremity robotic training in chronic stroke and spinal cord injury: individual neurophysiological and clinical responses.Journal of neuroengineering and rehabilitation · 2026Article
- No improvement in maximum jumping height in experienced and less experienced jumpers following a single session of transabdominal, transcutaneous spinal anodal direct current stimulation.Frontiers in physiology · 2026Article
- Effects of Transcranial and Trans-Spinal Direct Current Stimulation Combined with Robot-Assisted Gait Training on Gait and Fatigue in Patients with Multiple Sclerosis: A Double-Blind, Randomized, Sham-Controlled Study.Journal of clinical medicine · 2024Article
- From brain to spinal cord: neuromodulation by direct current stimulation and its promising effects as a treatment option for restless legs syndrome.Frontiers in neurology · 2024Review
- What Else Can Be Done by the Spinal Cord? A Review on the Effectiveness of Transpinal Direct Current Stimulation (tsDCS) in Stroke Recovery.International journal of molecular sciences · 2023Review
- The therapeutic effects of physical treatment for patients with hereditary spastic paraplegia: a narrative review.Frontiers in neurology · 2023Review
- Feasibility of transcutaneous spinal direct current stimulation combined with locomotor training after spinal cord injury.Spinal cord · 2022Article
- Adapting Human-Based Transcutaneous Spinal Cord Stimulation to Develop a Clinically Relevant Animal Model.Journal of clinical medicine · 2022Article
- Trans-Spinal Electrical Stimulation Therapy for Functional Rehabilitation after Spinal Cord Injury: Review.Journal of clinical medicine · 2022Review
- The effect of cathodal transspinal direct current stimulation on tibialis anterior stretch reflex components in humans.Experimental brain research · 2022Article
- Combined neuromuscular electrical stimulation and transcutaneous spinal direct current stimulation increases motor cortical plasticity in healthy humans.Frontiers in neuroscience · 2022Article
- Article
- Characterization of Motor-Evoked Responses Obtained with Transcutaneous Electrical Spinal Stimulation from the Lower-Limb Muscles after Stroke.Brain sciences · 2021Article
- Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?Physiological reports · 2021Review
- Feasibility and utility of transcutaneous spinal cord stimulation combined with walking-based therapy for people with motor incomplete spinal cord injury.Spinal cord series and cases · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spinal cord is an integration center for descending, ascending, and segmental neural signals. Noninvasive transspinal stimulation may thus constitute an effective method for concomitant modulation of local and distal neural circuits. In this study, we established changes in cortical excitability and input/output function of corticospinal and spinal neural circuits before, at 0-15 and at 30-45 minutes after cathodal, anodal, and sham transspinal direct current stimulation (tsDCS) to the thoracic region in healthy individuals. We found that intracortical inhibition was different among stimulation polarities, however remained unchanged over time. Intracortical facilitation increased after cathodal and anodal tsDCS delivered with subjects seated, and decreased after cathodal tsDCS delivered with subjects lying supine. Both cathodal and anodal tsDCS increased corticospinal excitability, yet facilitation was larger and persisted for 30 minutes post stimulation only when cathodal tsDCS was delivered with subjects lying supine. Spinal input/output reflex function was decreased by cathodal and not anodal tsDCS. These changes may be attributed to altered spontaneous neural activity and membrane potentials of corticomotoneuronal cells by tsDCS involving similar mechanisms to those mediating motor learning. Our findings indicate that thoracic tsDCS has the ability to concomitantly alter cortical, corticospinal, and spinal motor output in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.