ArticleNature communications2018
Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bad habits-good goals? Meta-analysis and translation of the habit construct to alcoholism.Translational psychiatry · 2024Pooled it
- Gray and white matter morphology in substance use disorders: a neuroimaging systematic review and meta-analysis.Translational psychiatry · 2021Pooled it
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Chronic ethanol exposure reduces resting state functional connectivity and regional synchrony in male rats.Psychopharmacology · 2026Article
- Revealing abrupt transitions from goal-directed to habitual behavior.Nature communications · 2026Article
- Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.bioRxiv : the preprint server for biology · 2026Article
- Sex differences in low-dose ethanol effects on motivated behavior and limbic corticostriatal activity in mice.Alcohol, clinical & experimental research · 2026Article
- Projection-specific roles of basolateral amygdala Thy1 neurons in alcohol-induced place preference.Molecular psychiatry · 2026Article
- Neurotoxic effects of chronic ethanol on cholinergic interneurons in the dorsomedial striatum.Neuropharmacology · 2026Article
- Sex Differences in Low-dose Ethanol Effects on Motivated Behavior and Limbic Corticostriatal Activity.bioRxiv : the preprint server for biology · 2025Article
- Disrupted decision making in adult male rats after prolonged withdrawal from ethanol vapor exposure.Alcohol, clinical & experimental research · 2025Article
- Alcohol effects on associative and sensorimotor cortico-thalamo-basal ganglia circuits alter decision making and alcohol intake.Alcohol (Fayetteville, N.Y.) · 2025Review
- Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex.Nature neuroscience · 2025Article
- Ethanol inhibits dorsomedial striatum acetylcholine release.bioRxiv : the preprint server for biology · 2025Article
- Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum.Science advances · 2025Article
- Effects of chronic ethanol exposure on dorsal medial striatal neurons receiving convergent inputs from the orbitofrontal cortex and basolateral amygdala.Neuropharmacology · 2025Article
- Chronic Ethanol Exposure Produces Persistent Impairment in Cognitive Flexibility and Decision Signals in the Striatum.bioRxiv : the preprint server for biology · 2025Article
- Striatal cell-type specific stability and reorganization underlying agency and habit.bioRxiv : the preprint server for biology · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Addiction involves a predominance of habitual control mediated through action selection processes in dorsal striatum. Research has largely focused on neural mechanisms mediating a proposed progression from ventral to dorsal lateral striatal control in addiction. However, over reliance on habit striatal processes may also arise from reduced cortical input to striatum, thereby disrupting executive control over action selection. Here, we identify novel mechanisms through which chronic intermittent ethanol exposure and withdrawal (CIE) disrupts top-down control over goal-directed action selection processes to produce habits. We find CIE results in decreased excitability of orbital frontal cortex (OFC) excitatory circuits supporting goal-directed control, and, strikingly, selectively reduces OFC output to the direct output pathway in dorsal medial striatum. Increasing the activity of OFC circuits restores goal-directed control in CIE-exposed mice. Our findings show habitual control in alcohol dependence can arise through disrupted communication between top-down, goal-directed processes onto basal ganglia pathways controlling action selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.