ArticleScientific reports2018
Evaluation of the effects of space allowance on measures of animal welfare in laboratory mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-Analysis of the Relationship Between Social Dominance Status and Common Behavioral Phenotypes in Male Laboratory Mice.Frontiers in behavioral neuroscience · 2020Pooled it
- Prevalence and management practices of ophthalmic lesions in laboratory mice.Scientific reports · 2026Article
- Ethological Constraints and Welfare-Related Bias in Laboratory Mice: Implications of Housing, Lighting, and Social Environment.Animals : an open access journal from MDPI · 2026Review
- A customised combination of environmental enrichment reduces aggression in CD-1 male mice.Laboratory animals · 2025Article
- Effects of Enclosure Size on the Preferences of Juvenile Chinchillas (Animals : an open access journal from MDPI · 2025Article
- Study on Adult Chinchilla (Animals : an open access journal from MDPI · 2024Article
- ATP1A1-linked diseases require a malfunctioning protein product from one allele.Biochimica et biophysica acta. Molecular cell research · 2024Article
- A bespoke water T-maze apparatus and protocol: an optimized, reliable, and repeatable method for screening learning, memory, and executive functioning in laboratory mice.Frontiers in behavioral neuroscience · 2024Article
- The horizontal ladder test (HLT) protocol: a novel, optimized, and reliable means of assessing motor coordination inFrontiers in behavioral neuroscience · 2024Article
- Mice Recognise Mice in Neighbouring Rearing Cages and Change Their Social Behaviour.Behavioural neurology · 2024Article
- The Horizontal Ladder Test (HLT) protocol: A novel, optimized, and reliable means of assessing motor coordination inbioRxiv : the preprint server for biology · 2023Article
- The 3Rs in Experimental Liver Disease.Animals : an open access journal from MDPI · 2023Review
- Aggression in Group-Housed Male Mice: A Systematic Review.Animals : an open access journal from MDPI · 2022Review
- Modeling Parkinson's disease-related symptoms in alpha-synuclein overexpressing mice.Brain and behavior · 2022Review
- Structural Degradation in Midcingulate Cortex Is Associated with Pathological Aggression in Mice.Brain sciences · 2021Article
- Quantification of Hair Corticosterone, DHEA and Testosterone as a Potential Tool for Welfare Assessment in Male Laboratory Mice.Animals : an open access journal from MDPI · 2020Article
- The epidemiology of fighting in group-housed laboratory mice.Scientific reports · 2020Article
- Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0.PLoS biology · 2020Article
- Adaptation of Mitochondrial Substrate Flux in a Mouse Model of Nonalcoholic Fatty Liver Disease.International journal of molecular sciences · 2020Article
- Effect of Ground Transportation on Adrenocortical Activity in Prepuberal Female Mice from Five Different Genetic Backgrounds.Animals : an open access journal from MDPI · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We studied how space allowance affects measures of animal welfare in mice by systematically varying group size and cage type across three levels each in both males and females of two strains of mice (C57BL/6ByJ and BALB/cByJ; n = 216 cages, a total of 1152 mice). This allowed us to disentangle the effects of total floor area, group size, stocking density, and individual space allocation on a broad range of measures of welfare, including growth (food and water intake, body mass); stress physiology (glucocorticoid metabolites in faecal boli); emotionality (open field behaviour); brain function (recurrent perseveration in a two-choice guessing task); and home-cage behaviour (activity, stereotypic behaviour). While increasing group size was associated with a decrease in food and water intake in general, and more specifically with increased attrition due to escalated aggression in male BALB mice, no other consistent effects of any aspect of space allowance were found with respect to the measures studied here. Our results indicate that within the range of conditions commonly found in laboratory mouse housing, space allowance as such has little impact on measures of welfare, except for group size which may be a risk factor for escalating aggression in males of some strains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.