Evidence map›Paper›PMID 29335418›Full record

ArticleScientific reports2018

Gender-specific association of early age-related macular degeneration with systemic and genetic factors in a Japanese population.

Mariko Sasaki, Sei Harada, Yumiko Kawasaki, Miki Watanabe, Hidemi Ito, Hideo Tanaka, Ayano Takeuchi, Kazuo Tsubota, Toru Takebayashi, Yuji Nishiwaki and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Mariko SasakiKeio University, Department of Ophthalmology, 160-0016, Tokyo, Japan.
Sei HaradaDepartment of Preventive Medicine and Public Health, Keio University, 160-8582, Tokyo, Japan.
Yumiko KawasakiYamagata University Graduate School of Medical Science, Department of Public Health, 990-2331, Yamagata, Japan.
Miki WatanabeNagoya City University Graduate School of Medical Sciences, Department of Public Health, 467-8601, Aichi, Japan.
Hidemi ItoAichi Cancer Research Institute, Division of Molecular & Clinical Epidemiology, 464-8681, Aichi, Japan.ORCID http://orcid.org/0000-0002-8023-4581
Hideo TanakaKishiwada Public Health Center, 596-0076, Osaka, Japan.
Ayano TakeuchiDepartment of Preventive Medicine and Public Health, Keio University, 160-8582, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0908-1850
Kazuo TsubotaKeio University, Department of Ophthalmology, 160-0016, Tokyo, Japan.ORCID http://orcid.org/0000-0002-8874-7111
Toru TakebayashiDepartment of Preventive Medicine and Public Health, Keio University, 160-8582, Tokyo, Japan.
Yuji NishiwakiToho University, Department of Environmental and Occupational Health, 143-8540, Tokyo, Japan.
Ryo KawasakiYamagata University Graduate School of Medical Science, Department of Public Health, 990-2331, Yamagata, Japan. ryok@med.id.yamagata-u.ac.jp.
Keio University · JPYamagata University · JPAichi Cancer Center · JPKishiwada City Hospital · JPNagoya City University · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Tsuruoka Metabolomics Cohort Study included subjects aged 35-74 years from participants in annual health check-up programs in Tsuruoka, Japan. The gender-specific associations of early age-related macular degeneration (AMD) with systemic and genetic factors was assessed cross-sectionally. Of these, 3,988 subjects had fundus photographs of sufficient quality, and early AMD was present in 12.3% and 10.3% of men and women, respectively. In men, higher levels of high-density lipoprotein cholesterol and lower levels of triglycerides were associated with increased odds of having early AMD after adjusting for potential risk factors (for each 1 mmol/L increase, odds ratio [OR]: 1.61 and 0.78, 95% confidence interval [CI]: 1.17-2.23 and 0.64-0.96, respectively). In women, higher levels of total cholesterol and low-density lipoprotein cholesterol were associated with increased risk of having early AMD (OR: 1.21 and 1.26, 95% CI: 1.01-1.44 and 1.03-1.53, respectively). Sub-analysis demonstrated that women with ARMS2 A69S polymorphisms had a stronger risk for early AMD (OR: 3.25, 95% CI: 2.10-5.04) than men (OR: 1.65, 95% CI: 1.02-2.69). Differential associations of early AMD with both systemic and genetic factors by sex were demonstrated in a Japanese cohort, which suggests that disease process of early AMD could be different by sex.

Indexed as

AdultAgedCholesterol, HDLCholesterol, LDLCohort StudiesComplement Factor HFemaleHumansJapanLogistic ModelsMacular DegenerationMaleMiddle AgedOdds RatioPolymorphism, Single NucleotideProteinsARMS2 protein, humanCholesterol, HDLCholesterol, LDLComplement Factor HProteins

Identifiers

PMID29335418
PMCPMC5768785
OpenAlexW2783041271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.