Evidence map›Paper›PMID 29335372›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2018

All's well that ends well: why large species have short telomeres.

Rosa Ana Risques, Daniel E L Promislow

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
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  12. Comparison of telomere length measurement methods.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  13. The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  14. Telomeres and genomic evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  15. Understanding diversity in telomere dynamics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Article
  16. Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  17. The fetal programming of telomere biology hypothesis: an update.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rosa Ana RisquesDepartment of Pathology, University of Washington, Seattle, WA 98195, USA rrisques@uw.edu.
Daniel E L PromislowDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0001-7088-4495
University of Washington · US

Funding

Metabolome-Genome Associations for Determining Mechanisms of Aging in DrosophilaR01AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2015 to 2019
$1.8M
Mitochondrial biomarkers for early detection of cancer in ulcerative colitisR01CA181308 · NCI · UNIVERSITY OF WASHINGTON · PI RISQUES, ROSA ANA · 2014 to 2018
$1.4M
NCI NIH HHS R01 CA181308NIA NIH HHS R01 AG049494
6 · The paper itself

Abstract

Among mammal species, almost all life-history traits are strongly size dependent. This size dependence even occurs at a molecular level. For example, both telomere length and telomerase expression show a size-dependent threshold. With some exceptions, species smaller than approximately 2 kg express telomerase, while species larger than that do not. Among species greater than approximately 5 kg, telomeres tend to be short-less than 25 kb-while among smaller species, some species have short and some have long telomeres. Here, we present a model to explore the role of body size-dependent trade-offs in shaping this threshold. We assume that selection favours short telomeres as a mechanism to protect against cancer. At the same time, selection favours long telomeres as a protective mechanism against DNA damage and replicative senescence. The relative importance of these two selective forces will depend on underlying intrinsic mortality and risk of cancer, both of which are size-dependent. Results from this model suggest that a cost-benefit model for the evolution of telomere length could explain phylogenetic patterns observed within the Class Mammalia. In addition, the model suggests a general conceptual framework to think about the role that body size plays in the evolution of tumour suppressor mechanisms.This article is part of the theme issue 'Understanding diversity in telomere dynamics'.

Indexed as

Body SizeTelomere ShorteningAge FactorsAnimalsBiological EvolutionCellular SenescenceFemaleHumansMaleMammalsModels, TheoreticalNeoplasmsTelomeraseTelomereTelomerasebody sizecancercellular senescencelife-history evolutionPeto's paradoxtelomeres

Identifiers

PMID29335372
PMCPMC5784068
OpenAlexW2784195702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.