ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Recruitment of Additional Corticospinal Pathways in the Human Brain with State-Dependent Paired Associative Stimulation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The effects of transcranial direct-current stimulation (tDCS) on pain intensity of patients with fibromyalgia: a systematic review and meta-analysis.BMC neurology · 2023Pooled it
- Non-invasive brain stimulation for improving gait, balance, and lower limbs motor function in stroke.Journal of neuroengineering and rehabilitation · 2022Pooled it
- Impact of High-Definition Cathodal tDCS Preconditioning on Enhancing the Therapeutic Efficacy of iTBS Combined With FES for Improving Walking Function in Patients With Spinal Cord Injury: A Randomized Controlled Trial.CNS neuroscience & therapeutics · 2026Trial
- Trial
- Effects of Transcranial Direct Current Stimulation Combined with Peripheral Electrical Stimulation on Upper Limb Function Recovery in Stroke: A Systematic Review and Meta-Analysis.Brain sciences · 2026Review
- EEG-timed neuromuscular stimulation shapes ipsilateral TMS-evoked motor responses in humans.Clinical neurophysiology practice · 2026Article
- Neurofeedback-induced desynchronization of sensorimotor rhythm elicits pre-movement downregulation of intracortical inhibition that shortens simple reaction time in humans: A double-blind, sham-controlled randomized study.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Top-down and bottom-up stimulation techniques combined with action observation treatment in stroke rehabilitation: a perspective.Frontiers in neurology · 2023Review
- Short-term facilitation effects elicited by cortical priming through theta burst stimulation and functional electrical stimulation of upper-limb muscles.Experimental brain research · 2022Article
- Decoding personalized motor cortical excitability states from human electroencephalography.Scientific reports · 2022Article
- Neurostimulation for Stroke Rehabilitation.Frontiers in neuroscience · 2021Review
- Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment in Vestibular Schwannoma: A Pilot Study.Frontiers in neurology · 2021Article
- Peripheral Electrical Stimulation Modulates Cortical Beta-Band Activity.Frontiers in neuroscience · 2021Article
- Brain-Machine Neurofeedback: Robotics or Electrical Stimulation?Frontiers in bioengineering and biotechnology · 2020Article
- State-Dependent Gain Modulation of Spinal Motor Output.Frontiers in bioengineering and biotechnology · 2020Article
- Motor learning enhanced by combined motor imagery and noninvasive brain stimulation is associated with reduced short-interval intracortical inhibition.Brain and behavior · 2019Article
- Paired Associative Electroacupuncture and Transcranial Magnetic Stimulation in Humans.Frontiers in human neuroscience · 2019Article
- Distinct Beta-band Oscillatory Circuits Underlie Corticospinal Gain Modulation.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Modulating functional connectivity after stroke with neurofeedback: Effect on motor deficits in a controlled cross-over study.NeuroImage. Clinical · 2018Article
- Hierarchical Bayesian estimation of motor-evoked potential recruitment curves yields accurate and robust estimates.Brain stimulationArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Standard brain stimulation protocols modify human motor cortex excitability by modulating the gain of the activated corticospinal pathways. However, the restoration of motor function following lesions of the corticospinal tract requires also the recruitment of additional neurons to increase the net corticospinal output. For this purpose, we investigated a novel protocol based on brain state-dependent paired associative stimulation.Motor imagery (MI)-related electroencephalography was recorded in healthy males and females for brain state-dependent control of both cortical and peripheral stimulation in a brain-machine interface environment. State-dependency was investigated with concurrent, delayed, and independent stimulation relative to the MI task. Specifically, sensorimotor event-related desynchronization (ERD) in the β-band (16-22 Hz) triggered peripheral stimulation through passive hand opening by a robotic orthosis and transcranial magnetic stimulation to the respective cortical motor representation, either synchronously or subsequently. These MI-related paradigms were compared with paired cortical and peripheral input applied independent of the brain state. Cortical stimulation resulted in a significant increase in corticospinal excitability only when applied brain state-dependently and synchronously to peripheral input. These gains were resistant to a depotentiation task, revealed a nonlinear evolution of plasticity, and were mediated via the recruitment of additional corticospinal neurons rather than via synchronization of neuronal firing. Recruitment of additional corticospinal pathways may be achieved when cortical and peripheral inputs are applied concurrently, and during β-ERD. These findings resemble a gating mechanism and are potentially important for developing closed-loop brain stimulation for the treatment of hand paralysis following lesions of the corticospinal tract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.