ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Single Bursts of Individual Granule Cells Functionally Rearrange Feedforward Inhibition.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Ultra-high-density Neuropixels probes improve detection and identification in neuronal recordings.Neuron · 2025Article
- Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices.Hippocampus · 2025Article
- Recurrent Interneuron Connectivity Does Not Support Synchrony in a Biophysical Dentate Gyrus Model.eNeuro · 2025Article
- Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area.Nature communications · 2025Article
- Intrinsic and Synaptic Contributions to Repetitive Spiking in Dentate Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Ultra-high density electrodes improve detection, yield, and cell type identification in neuronal recordings.bioRxiv : the preprint server for biology · 2024Article
- Auditory Corticofugal Neurons Transmit Auditory and Non-auditory Information During Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Phase information is conserved in sparse, synchronous population-rate-codes via phase-to-rate recoding.Nature communications · 2023Article
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- Memory discrimination is promoted by the expression of the transcription repressor WT1 in the dentate gyrus.Frontiers in behavioral neuroscience · 2023Article
- Reorganization of Parvalbumin Immunopositive Perisomatic Innervation of Principal Cells in Focal Cortical Dysplasia Type IIB in Human Epileptic Patients.International journal of molecular sciences · 2022Article
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- Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease.Frontiers in synaptic neuroscience · 2022Article
- Article
- Linear-nonlinear cascades capture synaptic dynamics.PLoS computational biology · 2021Article
- Slow-decaying presynaptic calcium dynamics gate long-lasting asynchronous release at the hippocampal mossy fiber to CA3 pyramidal cell synapse.Synapse (New York, N.Y.) · 2020Article
- Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits.eLife · 2020Article
- Dentate gyrus circuits for encoding, retrieval and discrimination of episodic memories.Nature reviews. Neuroscience · 2020Review
- Quantitative firing pattern phenotyping of hippocampal neuron types.Scientific reports · 2019Article
- Synapse Type-Dependent Expression of Calcium-Permeable AMPA Receptors.Frontiers in synaptic neuroscience · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The sparse single-spike activity of dentate gyrus granule cells (DG GCs) is punctuated by occasional brief bursts of 3-7 action potentials. It is well-known that such presynaptic bursts in individual mossy fibers (MFs; axons of granule cells) are often able to discharge postsynaptic CA3 pyramidal cells due to powerful short-term facilitation. However, what happens in the CA3 network after the passage of a brief MF burst, before the arrival of the next burst or solitary spike, is not understood. Because MFs innervate significantly more CA3 interneurons than pyramidal cells, we focused on unitary MF responses in identified interneurons in the seconds-long postburst period, using paired recordings in rat hippocampal slices. Single bursts as short as 5 spikes in <30 ms in individual presynaptic MFs caused a sustained, large increase (tripling) in the amplitude of the unitary MF-EPSCs for several seconds in ivy, axo-axonic/chandelier and basket interneurons. The postburst unitary MF-EPSCs in these feedforward interneurons reached amplitudes that were even larger than the MF-EPSCs during the bursts in the same cells. In contrast, no comparable postburst enhancement of MF-EPSCs could be observed in pyramidal cells or nonfeedforward interneurons. The robust postburst increase in MF-EPSCs in feedforward interneurons was associated with significant shortening of the unitary synaptic delay and large downstream increases in disynaptic IPSCs in pyramidal cells. These results reveal a new cell type-specific plasticity that enables even solitary brief bursts in single GCs to powerfully enhance inhibition at the DG-CA3 interface in the seconds-long time-scales of interburst intervals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.