ArticleEMBO molecular medicine2018
Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement.
Article in EMBO molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 129 citations in OpenAlex.
- High-resolution spatial transcriptomics of irradiated submandibular glands treated with fortified fibrin hydrogels.iScience · 2026Article
- Radiation-Induced Volume Changes in the Parotid and Submandibular Glands, Intragland Dose Distribution, and Quality of Life Scores Over a Long Follow-Up Period.Advances in radiation oncology · 2026Article
- Targeting Post-Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual-Action Approach for Antioxidant and Immune Modulation.Advanced healthcare materials · 2026Article
- A Mouthful of Genomic Data: Single-Cell Insights into Salivary Gland Biology and Disease.Biology · 2026Review
- Radiation-Induced Salivary Gland Fibrosis: Mechanisms, Emerging Therapies, and Gelatin-Based Bioengineered Models.Gels (Basel, Switzerland) · 2026Review
- Targeted regeneration of post-radiation epithelium without promoting cancer recurrence.Research square · 2026Article
- Laminaria japonica Polysaccharide Alleviates Radiation-Induced Salivary Gland Injury by Promoting DNA Damage Repair.International dental journal · 2026Article
- Advances in oral disease models: a mini-review of developments from 2015 to 2025.Frontiers in dental medicine · 2026Review
- Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualization in epithelial tissues.Discovery immunology · 2026Article
- Stem/progenitor cell dynamics during salivary gland development and regeneration demonstrated by the double pulse-chase paradigm.Regenerative therapy · 2025Article
- Immunomodulation of salivary gland function due to cancer therapy.Oral diseases · 2025Review
- Regenerative potential of the intermediate filaments of albino rat parotid glands subjected to fractionated radiotherapy: an immunohistochemical analysis.Acta odontologica Scandinavica · 2025Article
- Regional atrophy, cellular plasticity, and regenerative potential in irradiated murine salivary glands.Acta oncologica (Stockholm, Sweden) · 2025Article
- Article
- Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling.bioRxiv : the preprint server for biology · 2025Article
- Salivary gland stem/progenitor cells: advancing from basic science to clinical applications.Cell regeneration (London, England) · 2025Review
- Mesenchymal stem cell therapies evidence in the treatment of irradiated salivary glands: A scoping review.Journal of clinical and experimental dentistry · 2024Review
- Neuropeptides regulate embryonic salivary gland branching through the FGF/FGFR pathway in aging klotho-deficient mice.Aging cell · 2024Article
- Cancer therapy-related salivary dysfunction.The Journal of clinical investigation · 2024Review
- A single dose of radiation elicits comparable acute salivary gland injury to fractionated radiation.Disease models & mechanisms · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co-morbidities. A potential regenerative strategy for replacing injured tissue is the reactivation of endogenous stem cells by targeted therapeutics. However, the identity of these cells, whether they are capable of regenerating the tissue, and the mechanisms by which they are regulated are unknown. Using
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.