ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2018
Prevalence of primary aldosteronism in primary care: a cross-sectional study.
Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- European Hypertension Guidelines: Similarities and What the Practicing Physician Should Keep in Mind.Journal of clinical medicine · 2026Review
- Added value of multiparametric MRI for diagnosing subcentimeter functional adrenal nodules in primary aldosteronism using CXCR4-targeted PET/MRI.European journal of nuclear medicine and molecular imaging · 2025Article
- Recurrent hypokalemia induced by primary aldosteronism due to unilateral adrenal adenoma. A case report.Journal of family medicine and primary care · 2025Article
- Observational
- Screening for primary aldosteronism in 1,181 Swedish primary care patients with hypertension.Frontiers in endocrinology · 2025Article
- Feasibility of primary aldosteronism diagnosis in initial evaluation without medication withdrawal or confirmatory tests.Endocrine · 2024Article
- Shifting paradigms in primary aldosteronism: reconsideration of screening strategy via integrating pathophysiological insights.Frontiers in endocrinology · 2024Review
- Diagnosis and management of primary hyperaldosteronism in patients with hypertension: a practical approach endorsed by the British and Irish Hypertension Society.Journal of human hypertension · 2024Review
- The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images.Diagnostics (Basel, Switzerland) · 2022Article
- Validation of Existing Clinical Prediction Tools for Primary Aldosteronism Subtyping.Diagnostics (Basel, Switzerland) · 2022Article
- CXCR4-directed [BMJ open · 2022Article
- Adrenal Venous Sampling Could Be Omitted before Surgery in Patients with Conn's Adenoma Confirmed by Computed Tomography and Higher Normal Aldosterone Concentration after Saline Infusion Test.Diagnostics (Basel, Switzerland) · 2022Article
- Article
- A case with primary hyperaldosteronism associated with chronic kidney disease.Radiology case reports · 2022Article
- The etiology of preeclampsia.American journal of obstetrics and gynecology · 2022Review
- Article
- Progress on Genetic Basis of Primary Aldosteronism.Biomedicines · 2021Review
- Is acute kidney injury after laparoscopic adrenalectomy related to the progression of chronic kidney disease in patients with primary aldosteronism?Investigative and clinical urology · 2021Article
- Eplerenone levels in maternal serum, cord blood, and breast milk during pregnancy and lactation.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review.Biomedicines · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrimary aldosteronism (PA) is the most frequent cause of secondary hypertension. Reported prevalences of PA vary considerably because of a large heterogeneity in study methodology.
aimTo examine the proportion of patients with PA among patients with newly diagnosed, never treated hypertension. DESIGN AND
settingA cross-sectional study set in primary care.
methodGPs measured aldosterone and renin in adult patients with newly diagnosed, never treated hypertension. Patients with elevated aldosterone-to-renin ratio and increased plasma aldosterone concentration underwent a saline infusion test to confirm or exclude PA. The source population was meticulously assessed to detect possible selection bias.
resultsOf 3748 patients with newly diagnosed hypertension, 343 patients were screened for PA. In nine out of 74 patients with an elevated aldosterone-to-renin ratio and increased plasma aldosterone concentration the diagnosis of PA was confirmed by a saline infusion test, resulting in a prevalence of 2.6% (95% confidence interval = 1.4 to 4.9). All patients with PA were normokalaemic and 8 out of 9 patients had sustained blood pressure >150/100 mmHg. Screened patients were younger (
conclusionIn this study a prevalence of PA of 2.6% in a primary care setting was established, which is lower than estimates reported from other primary care studies so far. This study supports the screening strategy as recommended by the Endocrine Society Clinical Practice Guideline. The low proportion of screened patients (9.2%), of the large cohort of eligible patients, reflects the difficulty of conducting prevalence studies in primary care clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.