SynthesisJournal of the American Heart Association2018
Preterm Delivery and Future Risk of Maternal Cardiovascular Disease: A Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
114 citing papers in PubMed, 7 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Clinical practice guideline of the Interamerican Society of Cardiology on primary prevention of cardiovascular disease in women.Archivos de cardiologia de Mexico · 2022Guideline
- Risk of developing metabolic syndrome after gestational diabetes mellitus - a systematic review and meta-analysis.Journal of endocrinological investigation · 2021Pooled it
- Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review.BMJ (Clinical research ed.) · 2020Pooled it
- Future Cardiovascular Disease Risk for Women With Gestational Hypertension: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Determinants of preterm birth among mothers who gave birth in East Africa: systematic review and meta-analysis.Italian journal of pediatrics · 2020Pooled it
- Mode of delivery and preterm birth in subsequent births: A systematic review and meta-analysis.PloS one · 2019Pooled it
- Spontaneous Preterm Birth and Subsequent Cardiovascular Mortality: Linked Registry Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Weight Change Between Pregnancies and Mortality Over 50 Years of Follow-Up.Obesity (Silver Spring, Md.) · 2026Article
- "Actionable" risk for preterm birth: patterns and prediction in California singleton births 2016-2020.BMC pregnancy and childbirth · 2026Article
- Stable angina in young women.European heart journal · 2026Review
- Trajectories of depressive symptoms across pregnancy and the extended postpartum period and future cardiovascular health.medRxiv : the preprint server for health sciences · 2026Article
- Cancer During Pregnancy: Navigating Clinical and Research Challenges.Current oncology (Toronto, Ont.) · 2026Review
- Adverse Pregnancy Outcomes and Long-Term Risk of Chronic Diseases: Evidence from the Findings of the Tehran Lipid and Glucose Study During a Quarter of a Century.International journal of endocrinology and metabolism · 2026Review
- Reconsidering the life-course implications of relative energy deficiency in sport on pregnancy outcomes.Journal of sport and health science · 2026Article
- A scoping review exploring women's experiences of cardiometabolic pregnancy complications and future cardiovascular health implications.NPJ cardiovascular health · 2026Article
- Adverse Pregnancy Outcomes and Cognitive Change in Older Women.Journal of women's health (2002) · 2026Article
- Five-year cardiovascular outcomes across hypertensive disorders of pregnancy subtypes: a propensity-matched analysis.Frontiers in cardiovascular medicine · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPreterm delivery (<37 weeks gestational age) affects 11% of all pregnancies, but data are conflicting whether preterm birth is associated with long-term adverse maternal cardiovascular outcomes. We aimed to systematically evaluate and summarize the evidence on the relationship between preterm birth and future maternal risk of cardiovascular diseases. METHODS AND
resultsA systematic search of MEDLINE and EMBASE was performed to identify relevant studies that evaluated the association between preterm birth and future maternal risk of composite cardiovascular disease, coronary heart disease, stroke, and death caused by cardiovascular or coronary heart disease and stroke. We quantified the associations using random effects meta-analysis. Twenty-one studies with over 5.8 million women, including over 338 000 women with previous preterm deliveries, were identified. Meta-analysis of studies that adjusted for potential confounders showed that preterm birth was associated with an increased risk of maternal future cardiovascular disease (risk ratio [RR] 1.43, 95% confidence interval [CI], 1.18, 1.72), cardiovascular disease death (RR 1.78, 95% CI, 1.42, 2.21), coronary heart disease (RR 1.49, 95% CI, 1.38, 1.60), coronary heart disease death (RR 2.10, 95% CI, 1.87, 2.36), and stroke (RR 1.65, 95% CI, 1.51, 1.79). Sensitivity analysis showed that the highest risks occurred when the preterm deliveries occurred before 32 weeks gestation or were medically indicated.
conclusionsPreterm delivery is associated with an increase in future maternal adverse cardiovascular outcomes, including a 2-fold increase in deaths caused by coronary heart disease. These findings support the assessment of preterm delivery in cardiovascular risk assessment in women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.