Evidence map›Paper›PMID 29335280›Full record

ArticleThe EMBO journal2018

Mapping protein interactions of sodium channel Na

Alexandros H Kanellopoulos, Jennifer Koenig, Honglei Huang, Martina Pyrski, Queensta Millet, Stéphane Lolignier, Toru Morohashi, Samuel J Gossage, Maude Jay, John E Linley and 7 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. An approach to targeting Nav1.7 for pain sensations.The Journal of clinical investigation · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. The pain target NaPflugers Archiv : European journal of physiology · 2024
    Article
  12. Anxiety and dysautonomia symptoms in patients with a NaClinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
  13. Article
  14. NaExperimental neurology · 2023
    Article
  15. Article
  16. Article
  17. Review
  18. Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases.International journal of molecular sciences · 2022
    Review
  19. Article
  20. The HumanFrontiers in molecular neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 3 countries.

Alexandros H KanellopoulosMolecular Nociception Group, WIBR, University College London, London, UK.
Jennifer KoenigMolecular Nociception Group, WIBR, University College London, London, UK.
Honglei HuangTDI Mass Spectrometry Laboratory, Target Discovery Institute, University of Oxford, Oxford, UK.
Martina PyrskiCenter for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.ORCID 0000-0002-5751-178X
Queensta MilletMolecular Nociception Group, WIBR, University College London, London, UK.
Stéphane LolignierMolecular Nociception Group, WIBR, University College London, London, UK.
Toru MorohashiMolecular Nociception Group, WIBR, University College London, London, UK.
Samuel J GossageMolecular Nociception Group, WIBR, University College London, London, UK.
Maude JayMolecular Nociception Group, WIBR, University College London, London, UK.
John E LinleyMolecular Nociception Group, WIBR, University College London, London, UK.
Georgios BaskozosDivision of Bioscience, University College London, London, UK.ORCID 0000-0001-9237-5878
Benedikt M KesslerTDI Mass Spectrometry Laboratory, Target Discovery Institute, University of Oxford, Oxford, UK.
James J CoxMolecular Nociception Group, WIBR, University College London, London, UK.
Annette C DolphinDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
Frank ZufallCenter for Integrative Physiology and Molecular Medicine, Saarland University, Homburg, Germany.
John N WoodMolecular Nociception Group, WIBR, University College London, London, UK j.wood@ucl.ac.uk jing02.zhao@ucl.ac.uk.
Jing ZhaoMolecular Nociception Group, WIBR, University College London, London, UK j.wood@ucl.ac.uk jing02.zhao@ucl.ac.uk.ORCID 0000-0003-2587-1198
Wolfson Foundation · GBSaarland University · DEUniversity of Oxford · GBAstraZeneca (United Kingdom) · GBInserm · FRUniversity College London · GBUniversity of East London · GB

Funding

Medical Research Council G091905Medical Research Council G1100340Medical Research Council MR/R014132/1Wellcome TrustWellcome Trust 101054/Z/13/ZWellcome Trust 200183/Z/15/Z
6 · The paper itself

Abstract

The voltage-gated sodium channel Na

Indexed as

AcetamidesAnalgesicsAnimalsCell LineHEK293 CellsHumansIntercellular Signaling Peptides and ProteinsLacosamideMiceMice, Inbred C57BLMice, TransgenicNAV1.7 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPainProtein BindingProtein Interaction MappingAcetamidesAnalgesicscollapsin response mediator protein-2Gprin1 protein, mouseIntercellular Signaling Peptides and ProteinsLacosamideNAV1.7 Voltage-Gated Sodium ChannelNerve Tissue ProteinsReceptors, N-Methyl-D-AspartateReceptors, OpioidSCN3B protein, mouseScn9a protein, mouseSynaptotagmin IISyt2 protein, mouseTmed10 protein, mouseVesicular Transport ProteinsVoltage-Gated Sodium Channel beta-3 SubunitNaV1.7painprotein–protein interactorsensory neuronsodium channel

Identifiers

PMID29335280
PMCPMC5793798
OpenAlexW2602677564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.