Evidence map›Paper›PMID 29335243›Full record

ArticleJournal of the American Society of Nephrology : JASN2018

Nephronectin Regulates Mesangial Cell Adhesion and Behavior in Glomeruli.

Susan E Zimmerman, Chitkale Hiremath, Jun Tsunezumi, Zhufeng Yang, Bronwyn Finney, Denise K Marciano

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. I-mfa, Mesangial Cell TRPC1 Channel, and Regulation of GFR.Journal of the American Society of Nephrology : JASN · 2025
    Article
  6. Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. A cell-ECM mechanism for connecting the ipsilateral eye to the brain.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  15. Identification of an Altered Matrix Signature in Kidney Aging and Disease.Journal of the American Society of Nephrology : JASN · 2021
    Article
  16. The Glomerulus According to the Mesangium.Frontiers in medicine · 2021
    Review
  17. Article
  18. Article
  19. Alport syndrome and Pierson syndrome: Diseases of the glomerular basement membrane.Matrix biology : journal of the International Society for Matrix Biology · 2018
    Review
  20. Maintenance and Breakdown of Glomerular Tuft Architecture.Journal of the American Society of Nephrology : JASN · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Susan E ZimmermanDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Chitkale HiremathDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Jun TsunezumiDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Zhufeng YangDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Bronwyn FinneyDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
Denise K MarcianoDivision of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas denise.marciano@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · US

Funding

UT Southwestern O'Brien Kidney Research Core CenterP30DK079328 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MOE, ORSON W · 2007 to 2021
$16.9M
Role of afadin signaling in nephron tubulogenesisR01DK099478 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MARCIANO, DENISE K · 2014 to 2018
$1.7M
NIDDK NIH HHS P30 DK079328NIDDK NIH HHS R01 DK099478
6 · The paper itself

Abstract

A critical aspect of kidney function occurs at the glomerulus, the capillary network that filters the blood. The glomerular basement membrane (GBM) is a key component of filtration, yet our understanding of GBM interactions with mesangial cells, specialized pericytes that provide structural stability to glomeruli, is limited. We investigated the role of nephronectin (

Indexed as

AnimalsCell AdhesionCell CountEpithelial CellsExtracellular Matrix ProteinsFemaleFocal AdhesionsGene DeletionGlomerular Basement MembraneGlomerular MesangiumIntegrinsKidney GlomerulusMaleMiceMice, Mutant StrainsOrgan SpecificityExtracellular Matrix Proteinsintegrin alpha8beta1IntegrinsNpnt protein, mousecell biology and structurecell-matrix-interactionsglomerular basement membranemesangial cellsnephronectin

Identifiers

PMID29335243
PMCPMC5875951
OpenAlexW2783644940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.