Evidence map›Paper›PMID 29335068›Full record

ArticleBMB reports2018

Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4.

Yoo-Wook Kwon, Hyo-Suk Ahn, Joo-Young Park, Han-Mo Yang, Hyun-Jai Cho, Hyo-Soo Kim

Open access · goldAbstract readNews
PubMed Full text at PMC Publisher
In one paragraph

Article in BMB reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yoo-Wook KwonBiomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea.
Hyo-Suk AhnDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.
Joo-Young ParkNational Research Laboratory for Stem Cell Niche, Seoul National University, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080, Korea.
Han-Mo YangDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Hyun-Jai ChoDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.
Hyo-Soo KimDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080; National Research Laboratory for Stem Cell Niche, Seoul National University, Biomedical Research Institute, Seoul National University Hospital, Seoul 03080; Department of Internal Medicine, Seoul National University Hospital, Seoul 03080; Strategic Center of Cell and Bio Therapy for Heart, Diabetes & Cancer, Seoul National University Hospital, Seoul 03080, Korea.
Seoul National University Hospital · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced pluripotent stem cells (iPSCs) show great promise for replacing current stem cell therapies in the field of regenerative medicine. However, the original method for cellular reprogramming, involving four exogenous transcription factors, is characterized by low efficiency. Here, we focused on using epigenetic modifications to enhance the reprogramming efficiency. We hypothesized that there would be a new reprogramming factor involved in DNA demethylation, acting on the promoters of pluripotency-related genes. We screened proteins that bind to the methylated promoter of Oct4 and identified Zinc finger protein 127 (Zfp127), the functions of which have not yet been identified. We found that Zfp127 binds to the Oct4 promoter. Overexpression of Zfp127 in fibroblasts induced demethylation of the Oct4 promoter, thus enhancing Oct4 promoter activity and gene expression. These results demonstrate that Zfp127 is a novel regulator of Oct4, and may become a potent target to improve cellular reprogramming. [BMB Reports 2018; 51(5): 242-248].

Indexed as

Genomic ImprintingAnimalsDNA MethylationLuciferasesMice, Inbred C57BLNanog Homeobox ProteinOctamer Transcription Factor-3Pluripotent Stem CellsPromoter Regions, GeneticProtein BindingRibonucleoproteinsUbiquitin-Protein LigasesZinc FingersLuciferasesMkrn3 protein, mouseNanog Homeobox ProteinOctamer Transcription Factor-3Pou5f1 protein, mouseRibonucleoproteinsUbiquitin-Protein Ligases

Identifiers

PMID29335068
PMCPMC5988579
OpenAlexW2806627946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.