Evidence map›Paper›PMID 29335041›Full record

ArticleInternational psychogeriatrics2019

Clinical correlates of resilience factors in geriatric depression.

Kelsey T Laird, Helen Lavretsky, Pattharee Paholpak, Roza M Vlasova, Michael Roman, Natalie St Cyr, Prabha Siddarth

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International psychogeriatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. A Randomized Double-Blind Placebo-Controlled Trial of Combined Escitalopram and Memantine for Older Adults With Major Depression and Subjective Memory Complaints.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
    Trial
  5. Trial
  6. Review
  7. Review
  8. The role of brain health and resilience in reshaping trajectories of late-life neuropsychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  9. Review
  10. Article
  11. Reimagining Resilience in Aging: Leveraging AI/ML, Big Data Analytics, and Systems Innovation.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Resilience in Older People: A Concept Analysis.Healthcare (Basel, Switzerland) · 2023
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kelsey T LairdDepartment of Psychiatry,Semel Institute for Neuroscience and Human Behavior at UCLA,Los Angeles,California,USA.ORCID 0000-0002-3194-2522
Helen LavretskyDepartment of Psychiatry,Semel Institute for Neuroscience and Human Behavior at UCLA,Los Angeles,California,USA.
Pattharee PaholpakVisiting Research Scholar,Semel Institute for Neuroscience and Human Behavior,UCLA,Los Angeles,California,USA.
Roza M VlasovaDepartment of Psychiatry,Semel Institute for Neuroscience and Human Behavior at UCLA,Los Angeles,California,USA.
Michael RomanDavid Geffen School of Medicine at UCLA,Los Angeles,California,USA.
Natalie St CyrDepartment of Psychiatry,Semel Institute for Neuroscience and Human Behavior at UCLA,Los Angeles,California,USA.
Prabha SiddarthDepartment of Psychiatry,Semel Institute for Neuroscience and Human Behavior at UCLA,Los Angeles,California,USA.
Center for Neurosciences · USKhon Kaen University · THUniversity of California, Los Angeles · US

Funding

Brain connectivity and response to Tai Chi in geriatric depressionR01AT008383 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2015 to 2019
$4.1M
Brain aging and treatment response in geriatric depressionR01MH097892 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2013 to 2017
$3.5M
Methylphenidate Use to Improve Outcomes in Geriatric DepressionR01MH077650 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2008 to 2012
$1.8M
Mentoring and Research in Translational Science of Integrative MedicineK24AT009198 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Helen Lavretsky · 2016 to 2026
$1.4M
Neurobiological Mechanisms of Treatment Response in Geriatric DepressionK24MH086481 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LAVRETSKY, HELEN · 2010 to 2014
$906k
NCCIH NIH HHS K24 AT009198NCCIH NIH HHS R01 AT008383NIMH NIH HHS K24 MH086481NIMH NIH HHS R01 MH077650NIMH NIH HHS R01 MH097892
6 · The paper itself

Abstract

ABSTRACTBackground:Traditional perspectives conceptualize resilience as a trait and depression as resulting from resilience deficiency. However, research indicates that resilience varies substantially even among adults who are clinically depressed, as well as across the lifespan of an individual. Few studies have investigated resilience in depression, and even fewer have examined resilience in depressed older adults.

methodsThree hundred thirty-seven adults ≥60 years with major depressive disorder completed the Connor-Davidson Resilience Scale (CD-RISC) and measures of mental health, quality of life (QOL), and medical comorbidity. Exploratory factor analysis was used to explore the factor structure of the CD-RISC. Correlations and general linear models were used to examine associations between resilience and other variables.

resultsThe rotated component matrix indicated a four-factor model. Sorting of items by highest factor loading revealed constructs associated with (1) grit, (2) active coping self-efficacy, (3) accommodative coping self-efficacy, and (4) spirituality. Resilience was significantly correlated with increased age, lower cognitive functioning, greater cerebrovascular risk, and greater medical comorbidity. Resilience was negatively associated with mental health symptoms (depression, apathy, and anxiety) and positively associated with QOL. The final optimal model identified less depression, less apathy, greater medical comorbidity, higher QOL, and minority (non-White) race as factors that significantly explained variability in resilience.

conclusionsResilience was significantly associated with a range of mental health constructs in a sample of older adults with depression. Future clinical trials and dismantling studies may help determine whether interventions targeting grit, active coping, accommodative coping, and spirituality can increase resilience and help prevent and treat depression in older adults.

Indexed as

Resilience, PsychologicalAdaptation, PsychologicalAgedAgingFactor Analysis, StatisticalFemaleGeriatric PsychiatryHumansMajor Depressive DisorderMaleMiddle AgedProtective FactorsPsychiatric Status Rating ScalesQuality of LifeSelf EfficacySurveys and QuestionnairesagingcomponentsdepressionEFAgeriatricresilienceresilientwell-being

Identifiers

PMID29335041
PMCPMC6047931
OpenAlexW2784108625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.