ArticleMalaria journal2018
Poor response to artesunate treatment in two patients with severe malaria on the Thai-Myanmar border.
Article in Malaria journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments.Molecules (Basel, Switzerland) · 2020Pooled it
- Spectrophotometric analysis of artesunate injections available in community pharmacies in Northern and Western Uganda.Future science OA · 2025Article
- Investigating the relationship betweenBMJ open · 2025Article
- Advancing artemisinin resistance monitoring using a high sensitivity ddPCR assay for Pfkelch13 mutation detection in Asia.Scientific reports · 2025Article
- Defining the next generation of severe malaria treatment: a target product profile.Malaria journal · 2024Review
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- Decoquinate liposomes: highly effective clearance of Plasmodium parasites causing severe malaria.Malaria journal · 2022Article
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Development and Validation of anAntimicrobial agents and chemotherapy · 2021Article
- Polymorphisms in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and multidrug-resistant gene 1 (Pfmdr-1) in Nigerian children 10 years post-adoption of artemisinin-based combination treatments.International journal for parasitology · 2021Article
- [PGE1-assisted treatment of microcirculation disturbance in complicated falciparum malaria].Der Anaesthesist · 2019Article
- Quinine - a time for re-evaluation?The Southern African journal of critical care : the official journal of the Critical Care Society · 2019Article
- Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination.Parasite (Paris, France) · 2018Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundMalaria has declined dramatically along the Thai-Myanmar border in recent years due to malaria control and elimination programmes. However, at the same time, artemisinin resistance has spread, raising concerns about the efficacy of parenteral artesunate for the treatment of severe malaria. CASE PRESENTATION: In November 2015 and April 2017, two patients were treated for severe malaria with parenteral artesunate. Quinine was added within 24 h due to an initial poor response to treatment. The first patient died within 24 h of starting treatment and the second did not clear his peripheral parasitaemia until 11 days later. Genotyping revealed artemisinin resistance Kelch-13 markers.
conclusionsReliable efficacy of artesunate for the treatment of severe malaria may no longer be assured in areas where artemisinin resistance has emerged. Empirical addition of parenteral quinine to artesunate for treatment is recommended as a precautionary measure.
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Registered trials
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