ArticleBMC psychiatry2018
Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population.
Article in BMC psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Association between triglyceride and depression: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls.Biological psychiatry · 2020Pooled it
- Association between serum lipid concentrations and attempted suicide in patients with major depressive disorder: A meta-analysis.PloS one · 2020Pooled it
- LDL-C modifies the association between triglycerides and depression identified by threshold scanning in US adults.Scientific reports · 2026Article
- Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation.Translational psychiatry · 2026Article
- Predicting peripartum depression using elastic net regression and machine learning: the role of remnant cholesterol.BMC pregnancy and childbirth · 2025Article
- A Clinical-Metabolic Prediction Model for Suicidal Behaviors Risk Stratification in First-Admission Major Depressive Disorder: A Cross-Sectional Analysis.Neuropsychiatric disease and treatment · 2025Article
- Biological Basis for the Formation of Suicidal Behavior: A Review.Medical journal of the Islamic Republic of Iran · 2025Review
- Article
- The Role of Serum Lipids in Predicting Suicidal Ideation in Isotretinoin Therapy for Acne.Psychiatry and clinical psychopharmacology · 2024Article
- Article
- Clarification of the molecular mechanisms underlying glyphosate-induced major depressive disorder: a network toxicology approach.Annals of general psychiatry · 2024Article
- Sex Differences in Suicide Attempts: A Cross-Sectional Study in Patients with First-Episode and Drug-Naïve Major Depression Disorder.Depression and anxiety · 2024Article
- The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study.Frontiers in psychiatry · 2024Article
- Elevated remnant cholesterol and the risk of prevalent major depressive disorder: a nationwide population-based study.Frontiers in psychiatry · 2024Article
- Association of remnant cholesterol with depression among US adults.BMC psychiatry · 2023Article
- Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis.World journal of clinical cases · 2023Article
- Article
- Relationship between serum lipids and depression: A cross sectional survey among adults in Haryana, India.Indian journal of psychiatry · 2023Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCholesterol has been associated as a risk factor for cardiovascular disease. Recently, however, there is growing evidence about crucial requirement of neuron membrane cholesterol in the organization and function of the 5-HT
methodsPlasma levels of total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-c) and low density lipoprotein cholesterol (LDL-c) were determined in 261 MDD patients meeting the DSM-5 criteria for major depressive disorder (MDD), 59 of whom had undergone an episode of suicide attempt, and 206 healthy controls.
resultsA significant decrease in total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglyceride serum levels was observed in the groups of MDD patients and suicide attempt compared to those without suicidal behavior (p < 0.05). After adjusting for covariates, lower cholesterol levels were significantly associated with MDD (OR 4.229 CI 95% 2.555 - 7.000, p<.001) and suicide attempt (OR 5.540 CI 95% 2.825 - 10.866, p<.001)
conclusionsThese results support the hypothesis that lower levels of cholesterol are associated with mood disorders like MDD and suicidal behavior. More mechanistic studies are needed to further explain this association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.