ArticleJournal of innate immunity2018
The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock.
Article in Journal of innate immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study.Journal of intensive care · 2025Article
- Genetic polymorphisms, biomarkers and signaling pathways associated with septic shock: from diagnosis to therapeutic targets.Burns & trauma · 2024Review
- The rs8506 TT Genotype inFrontiers in public health · 2022Article
- IL-20 Cytokines Are Involved in Epithelial Lesions Associated with Virus-Induced COPD Exacerbation in Mice.Biomedicines · 2021Article
- Significance of body temperature in elderly patients with sepsis.Critical care (London, England) · 2020Observational
- Who is WHO?Journal of innate immunity · 2020Article
- Serious, Severe, Sepsis.Journal of innate immunity · 2020Article
- Tackling the Pros and Cons of Inflammation.Journal of innate immunity · 2019Article
- The Balancing Act of Inflammation.Journal of innate immunity · 2018Article
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe IL10 family of genes includes crucial immune regulators. We tested the hypothesis that single nucleotide polymorphisms (SNPs) in IL10, IL19, IL20, and IL24 of the IL10 family gene cluster alter the clinical outcome of septic shock.
methodsPatients with septic shock (n = 1,193) were genotyped for 13 tag SNPs of IL10, IL19, IL20, and IL24. IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped for IL20 rs2981573 A/G. The primary outcome variable was 28-day mortality.
resultsPatients with the G allele of IL20 rs2981573 had a significantly increased hazard of death over the 28-day period compared to patients with the A allele in the septic shock cohort (adjusted hazard ratio 1.27; 95% confidence interval 1.10-1.47; p = 8.0 × 10-4). Patients with the GG genotype had more organ dysfunction (p < 0.05). The GG genotype was associated with increased IL20 gene expression in stimulated lymphoblastoid cells in vitro (p < 0.05). The cardiac surgical ICU patients with the GG genotype had an increased length of ICU stay (p = 0.032).
conclusionsThe GG genotype of IL20 rs2981573 SNP was associated with increased IL20 gene expression and increased adverse outcomes in patients with septic shock and following cardiac surgery.
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