Evidence map›Paper›PMID 29334561›Full record

ArticleAnnals of surgery2019

Preoperative 18F-FDG PET/CT in Pheochromocytomas and Paragangliomas Allows for Precision Surgery.

Pavel Nockel, Mustapha El Lakis, Apostolos Gaitanidis, Roxanne Merkel, Dhaval Patel, Naris Nilubol, Tamara Prodanov, Karel Pacak, Electron Kebebew

Open access · greenAbstract read
In one paragraph

Article in Annals of surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Imaging of Pheochromocytoma and Paraganglioma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Pavel NockelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
Mustapha El LakisEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
Apostolos GaitanidisEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
Roxanne MerkelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
Dhaval PatelEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
Naris NilubolEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
Tamara ProdanovSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD.
Electron KebebewEndocrine Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD.
National Institutes of Health · USGeorge Washington University · US

Funding

Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and ParagangliomaZIAHD008735 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PACAK, KAREL · 2009 to 2024
$28.4M
Therapeutic targets and novel anticancer agents for endocrine cancersZIABC011286 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI NILUBOL, NARIS · 2010 to 2025
$16.6M
EOB Clinical CoreZIDBC011534 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KEBEBEW, ELECTRON · 2014 to 2018
$4.8M
Intramural NIH HHS ZIA HD008735
6 · The paper itself

Abstract

backgroundFluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) imaging is recommended in patients with metastatic pheochromocytoma (PC) and paraganglioma (PGL). There are no data on whether routine preoperative F-FDG PET/CT in all patients with PC/PGL impacts surgical management.

objectiveThe aim of this study was to determine whether routine preoperative F-FDG PET/CT imaging affects the surgical management of patients with PC/PGLs.

methodsWe analyzed clinical, biochemical, genetic, and anatomic imaging data in 93 consecutive patients with PC/PGL who collectively underwent a total of 100 operations and who had preoperative F-FDG PET/CT imaging.

resultsOf 100 operations, preoperative F-FDG PET/CT showed additional lesions compared to anatomic imaging in 15 cases. These patients were more likely to undergo an open surgical approach (P < 0.05). Presence of genetic mutation, redo operations, sex, age, or tumor size had no significant association with finding additional lesions on F-FDG PET/CT.

conclusionsAdditional lesions detected on preoperative F-FDG-PET/CT imaging have an impact on the surgical approach in patients with PC/PGLs. Therefore, surgeons should routinely obtain F-FDG-PET/CT imaging in patients with PC/PGL to allow for a more precise surgical intervention.

Indexed as

Positron Emission Tomography Computed TomographyAdolescentAdrenalectomyAdrenal Gland NeoplasmsAdultAgedChildFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedParagangliomaPheochromocytomaPrecision MedicinePreoperative CareFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID29334561
PMCPMC7424912
OpenAlexW2784270436

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.